Biomaterial Database

Anti-Staphylococcus aureus-specific IgE in atopic dermatitis. 1986

C Motala, and P C Potter, and E G Weinberg, and D Malherbe, and J Hughes

Serum samples from 60 adults and 64 children with atopic dermatitis were tested for antistaphylococcal IgE antibodies with RAST discs coupled to cellular proteins from Wood 46 strain S. aureus. Anti-S. aureus IgE antibodies were detected in 19 (29.6%) of the children and 14 (23.3%) of the adult patients. Anti-S. aureus IgE-positive adults had more severe and prolonged disease than those who were negative. Two groups of children comprising 10 who were anti-S. aureus IgE positive and 10 who were negative were compared. Children with anti-S. aureus IgE antibodies had more severe and more extensive disease (p less than 0.05), a greater prevalence of cutaneous S. aureus infections (p less than 0.05), higher mean total serum IgE level (p less than 0.05), a greater prevalence of specific IgE responses to food allergens (p less than 0.05), and a higher percentage of helper T cells (p less than 0.05) than children who were negative for these antibodies.

UI	MeSH Term	Description	Entries
D007073	Immunoglobulin E	An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).	IgE
D008297	Male		Males
D011852	Radioallergosorbent Test	An in vitro allergen radioimmunoassay in which allergens are coupled to an immunosorbent. The coupled allergens bind the IgE in the sera of patients which in turn binds radioisotope-labeled anti-IMMUNOGLOBULIN E antibodies.	Radioimmunosorbent Assay of Allergens,Allergens Radioimmunosorbent Assay,Allergens Radioimmunosorbent Assays,Radioallergosorbent Tests,Test, Radioallergosorbent,Tests, Radioallergosorbent
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D003876	Dermatitis, Atopic	A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema.	Eczema, Atopic,Eczema, Infantile,Neurodermatitis, Atopic,Neurodermatitis, Disseminated,Atopic Dermatitis,Atopic Eczema,Atopic Neurodermatitis,Disseminated Neurodermatitis,Infantile Eczema
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D000907	Antibodies, Bacterial	Immunoglobulins produced in a response to BACTERIAL ANTIGENS.	Bacterial Antibodies
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.