Biomaterial Database

Oral solitary fibrous tumors: A collaborative clinicopathologic study of 19 cases. 2023

John Lennon Silva Cunha, and Israel Leal Cavalcante, and Elton Fernandes Barros, and Sebastião Silvério de Sousa Neto, and Roberta Barroso Cavalcante, and Eveline Turatti, and Elismauro Francisco de Mendonça, and Ricardo Luiz Cavalcanti de Albuquerque-Júnior, and Ana Lia Anbinder, and Décio Fragata da Silva, and Ivison Xavier Duarte, and Cassiano Francisco Weege Nonaka, and Pollianna Muniz Alves, and Oslei Paes de Almeida, and Bruno Augusto Benevenuto de Andrade

Oral Pathology Section, Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, Brazil.

OBJECTIVE To report the clinicopathologic features of 19 oral solitary fibrous tumors (SFTs). METHODS Clinical data were collected from the records of seven pathology services. All cases were re-evaluated by HE staining and confirmed by immunohistochemistry. RESULTS The series comprised 11 females (57.9%) and 8 males (42.1%), with a mean age of 47.3 ± 14.7 years (range: 22-71 years) and a 1.3:1 female-to-male ratio. Most tumors affected the buccal mucosa (n = 7; 36.8%) and presented clinically as an asymptomatic solitary submucosal well-circumscribed nodule with coloration similar to the oral mucosa. Morphologically, most SFTs (n = 10; 52.6%) exhibited a classic hybrid pattern characterized by a well-circumscribed proliferation of densely cellular areas alternating with hypocellular areas in a variably collagenous vascular stroma. Remnants of accessory salivary glands were observed in two cases (n = 2; 10.5%). All tumors were positive for STAT6 and CD34 (n = 19; 100%). Outcome information was available from 6 patients (31.6%), with clinical follow-up ranging from 6 to 24 months (mean ± SD, 9.5 ± 6.8 months), and none developed local recurrence. CONCLUSIONS Oral SFTs are rare and often clinically misdiagnosed. Pathologists should consider SFT in the differential diagnosis of oral spindle cell tumors. Accurate diagnosis requires careful morphological evaluation supported by immunohistochemical analysis.