Biomaterial Database

[Capillary isotachophoresis--a new method in drug analysis. 3. Analytic capillary isotachophoresis for the determination of amantadine and rimantadine]. 1986

R Jannasch

Investigations by means of analytical capillary isotachophoresis are possible not only for ampholytes, as peptides or amino acids, but generally for weak and strong electrolytes. Amantadine and rimantadine are determined by making use of a leading electrolyte including K+ ions at a pH range from 5.9 to 6.0 (terminating ion = creatinine+) at concentrations of the test solutions of greater than or equal to 600 nmol/ml and greater than or equal to nmol/ml, respectively, with a precision calculated as rel. S.D. (%) less than +/- 3 as a rule and a duration for one analysis less than 10 min. The tested discontinuous electrolyte system enables the determination of both the active substances simultaneously. The missing UV absorption of 1 and 2 is not disadvantageous by virtue of the application of the conductivity detector. The method was employed to carry out a content uniformity test for 2 tablets and informing experiments about the dissolution of 2 hydrochloride respectively 1 hydrochloride in water out of tablets and capsules, respectively.

UI	MeSH Term	Description	Entries
D002214	Capsules	Hard or soft soluble containers used for the oral administration of medicine.	Capsule,Microcapsule,Microcapsules
D004586	Electrophoresis	An electrochemical process in which macromolecules or colloidal particles with a net electric charge migrate in a solution under the influence of an electric current.	Electrophoreses
D000218	Adamantane	A tricyclo bridged hydrocarbon.	Diamantane
D000547	Amantadine	An antiviral that is used in the prophylactic or symptomatic treatment of influenza A. It is also used as an antiparkinsonian agent, to treat extrapyramidal reactions, and for postherpetic neuralgia. The mechanisms of its effects in movement disorders are not well understood but probably reflect an increase in synthesis and release of dopamine, with perhaps some inhibition of dopamine uptake.	1-Aminoadamantane,Adamantylamine,Adekin,Aman,Amanta,Amanta-HCI-AZU,Amanta-Sulfate-AZU,Amantadin AL,Amantadin AZU,Amantadin Stada,Amantadin-neuraxpharm,Amantadin-ratiopharm,Amantadina Juventus,Amantadina Llorente,Amantadine Hydrochloride,Amantadine Sulfate,Amixx,Cerebramed,Endantadine,Gen-Amantadine,Infecto-Flu,Infex,Mantadix,Midantan,PMS-Amantadine,Symadine,Symmetrel,Viregyt,Wiregyt,tregor,1 Aminoadamantane,AL, Amantadin,AZU, Amantadin,Amanta HCI AZU,Amanta Sulfate AZU,AmantaHCIAZU,AmantaSulfateAZU,Amantadin neuraxpharm,Amantadin ratiopharm,Amantadinneuraxpharm,Amantadinratiopharm,Gen Amantadine,GenAmantadine,Hydrochloride, Amantadine,Infecto Flu,InfectoFlu,Juventus, Amantadina,Llorente, Amantadina,PMS Amantadine,PMSAmantadine,Stada, Amantadin,Sulfate, Amantadine
D012299	Rimantadine	An RNA synthesis inhibitor that is used as an antiviral agent in the prophylaxis and treatment of influenza.	Remantadine,Flumadine,Riamantadine,Rimantadine Hydrochloride,Roflual,Hydrochloride, Rimantadine
D013056	Spectrophotometry, Ultraviolet	Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Ultraviolet Spectrophotometry
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet