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Endosulfan, a chlorinated pesticide, is widely used to control various insect pests. Rats exposed to 1 mg and 3 mg endosulfan/kg for periods of 10, 30, and 60 days showed significant (P less than 0.05) inhibition of [3H]5-hydroxytryptamine (5-HT) uptake by platelet-rich plasma (PRP) in an ex vivo study. Rats treated with endosulfan (1 and 3 mg/kg) up to 60 days elucidated a marked inhibition of ADP-induced aggregatory responses of the platelets. Incubation of PRP with 10 microM and 100 microM endosulfan for 15 min at 37 degrees C also resulted in significant (P less than 0.05) inhibition of platelet aggregation in vitro. The paper discusses the use of rat blood platelets as a model for the study of neuro- and cardiovascular toxicity of endosulfan.
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
April 1988,
Journal of neurochemistry,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
April 1974,
The Journal of pharmacology and experimental therapeutics,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
June 1987,
European journal of pharmacology,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
November 1984,
Naunyn-Schmiedeberg's archives of pharmacology,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
January 1990,
Current medical research and opinion,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
June 1961,
British journal of pharmacology and chemotherapy,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
January 1994,
European journal of clinical pharmacology,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
January 1980,
Psychopharmacology,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
July 1990,
International journal of clinical pharmacology, therapy, and toxicology,
M Anand, and
K Gopal, and
C Agrawal, and
S V Chandra, and
P K Ray, and
M Verma, and
K Shanker
August 1957,
The Journal of physiology,
