Biomaterial Database

Relationship of arterial wedge pressure to closing pressure in the pulmonary circulation. 1986

A C Jasper, and S L Soohoo, and H S Goldberg

We studied the relationship between the pulmonary artery wedge pressure (Pw) and pulmonary venous pressure (Ppv) at 2 alveolar pressures (PA) in 7 isolated perfused dog lobes. If PA were the critical pressure in the pulmonary circulation, one would expect Pw to equal Ppv for all Ppv greater than PA. Relative to the hilum, the average critical pressure in these lobes was 15.07 +/- 0.40 cmH2O at PA = 5 cmH2O and increased significantly to 17.23 +/- 0.82 cmH2O at PA = 7 cmH2O. Because the critical pressure in fact exceeded PA, Pw was found to be relatively constant and independent of Ppv even when Ppv exceeded PA by 5 cmH2O or more. For example, at PA = 5.13 +/- 0.04 cmH2O and Ppv = 9.64 +/- 0.28, the mean value for Pw was 13.30 +/- 0.59 cmH2O. Pw is equal neither to the average critical pressure nor to PA, but instead lies between these two values. It is determined by the spectrum of closing pressures in the pulmonary circulation, and the time-constants for drainage of beds downstream from the occluded pulmonary arterial branch.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D011650	Pulmonary Alveoli	Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.	Alveoli, Pulmonary,Alveolus, Pulmonary,Pulmonary Alveolus
D011652	Pulmonary Circulation	The circulation of the BLOOD through the LUNGS.	Pulmonary Blood Flow,Respiratory Circulation,Circulation, Pulmonary,Circulation, Respiratory,Blood Flow, Pulmonary,Flow, Pulmonary Blood,Pulmonary Blood Flows
D011669	Pulmonary Wedge Pressure	The blood pressure as recorded after wedging a CATHETER in a small PULMONARY ARTERY; believed to reflect the PRESSURE in the pulmonary CAPILLARIES.	Pulmonary Artery Wedge Pressure,Pulmonary Capillary Wedge Pressure,Pulmonary Venous Wedge Pressure,Wedge Pressure,Pressure, Pulmonary Wedge,Pressures, Pulmonary Wedge,Pulmonary Wedge Pressures,Wedge Pressure, Pulmonary,Wedge Pressures, Pulmonary,Pressure, Wedge,Pressures, Wedge,Wedge Pressures
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D005260	Female		Females
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014690	Venous Pressure	The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.	Blood Pressure, Venous,Blood Pressures, Venous,Pressure, Venous,Pressure, Venous Blood,Pressures, Venous,Pressures, Venous Blood,Venous Blood Pressure,Venous Blood Pressures,Venous Pressures
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In