| D010003 |
Osteoarthritis |
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans. |
Arthritis, Degenerative,Osteoarthrosis,Osteoarthrosis Deformans,Arthroses,Arthrosis,Arthritides, Degenerative,Degenerative Arthritides,Degenerative Arthritis,Osteoarthritides,Osteoarthroses |
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| D006377 |
T-Lymphocytes, Helper-Inducer |
Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions. |
Helper Cell,Helper Cells,Helper T Cell,Helper-Inducer T-Lymphocytes,Inducer Cell,Inducer Cells,T-Cells, Helper-Inducer,T-Lymphocytes, Helper,T-Lymphocytes, Inducer,Helper T-Cells,Cell, Helper T,Cells, Helper T,Helper Inducer T Lymphocytes,Helper T Cells,Helper T-Cell,Helper T-Lymphocyte,Helper T-Lymphocytes,Helper-Inducer T-Cell,Helper-Inducer T-Cells,Helper-Inducer T-Lymphocyte,Inducer T-Lymphocyte,Inducer T-Lymphocytes,T Cell, Helper,T Cells, Helper,T Cells, Helper Inducer,T Lymphocytes, Helper,T Lymphocytes, Helper Inducer,T Lymphocytes, Inducer,T-Cell, Helper,T-Cell, Helper-Inducer,T-Cells, Helper,T-Lymphocyte, Helper,T-Lymphocyte, Helper-Inducer,T-Lymphocyte, Inducer |
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| D006801 |
Humans |
Members of the species Homo sapiens. |
Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man |
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| D000079424 |
Tumor Necrosis Factor Inhibitors |
Compounds or agents that bind to and inhibit the synthesis or activity of TUMOR NECROSIS FACTOR-alpha. Such agents are used to treat inflammatory bowel diseases and other inflammatory diseases. |
TNF Antagonist,TNF Blocker,TNF Inhibitor,Tumor Necrosis Factor Antagonist,Tumor Necrosis Factor Blocker,Tumor Necrosis Factor Inhibitor,Tumor Necrosis Factor-a (TNF-a) Antagonist,Tumor Necrosis Factor-a (TNF-a) Blocker,Tumor Necrosis Factor-a (TNF-a) Inhibitor,TNF Antagonists,TNF Blockers,TNF Inhibitors,Tumor Necrosis Factor Antagonists,Tumor Necrosis Factor Blockers,Tumor Necrosis Factor-a (TNF-a) Antagonists,Tumor Necrosis Factor-a (TNF-a) Blockers,Tumor Necrosis Factor-a (TNF-a) Inhibitors,Antagonist, TNF,Antagonists, TNF,Blocker, TNF,Blockers, TNF,Inhibitor, TNF,Inhibitors, TNF |
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| D000084522 |
T Follicular Helper Cells |
A specialized subpopulation of CD4+ T cells involved in formation of GERMINAL CENTER. Tfh cells are mostly located in secondary lymphoid organs, e.g., TONSIL; SPLEEN and LYMPH NODES. They are CD4 ANTIGEN; CD45 ANTIGEN; B-CELL LYMPHOMA 6 PROTEIN; CXCR5 RECEPTORS; ICOS INDUCIBLE T-CELL CO-STIMULATOR; and PD1 RECEPTOR positive. |
Follicular B Helper T Cells,Follicular Helper T Cells,Tfh Cells,Tfh Cell |
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| D001172 |
Arthritis, Rheumatoid |
A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated. |
Rheumatoid Arthritis |
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| D013582 |
Synovial Fluid |
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints. |
Synovia,Fluid, Synovial,Fluids, Synovial,Synovial Fluids |
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| D014409 |
Tumor Necrosis Factor-alpha |
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. |
Cachectin,TNF-alpha,Tumor Necrosis Factor Ligand Superfamily Member 2,Cachectin-Tumor Necrosis Factor,TNF Superfamily, Member 2,TNFalpha,Tumor Necrosis Factor,Cachectin Tumor Necrosis Factor,Tumor Necrosis Factor alpha |
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| D016207 |
Cytokines |
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner. |
Cytokine |
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