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The reported incidence of peptic ulcer disease (PUD) in patients with rheumatoid arthritis (RA) is higher than that of the general population. Unusual susceptibility to PUD in RA, independent of therapy, has been suggested. To compare RA patients with others who had similar drug exposure but no known predisposition to PUD, 120 patients hospitalized for treatment of severe arthritis (65 with RA, 55 with osteoarthritis) were assessed by questionnaire for PUD history, drug history and other relevant variables. The relationship of PUD to sex distribution, smoking, alcohol consumption and anti-inflammatory therapy followed expected patterns. We found high but similar PUD rates in RA and osteoarthritis (OA) patients (RA 15%, OA 18%). This suggests that a common factor (probably drugs) is responsible. We feel that the documented high incidence of PUD in RA is most probably related to drug therapy. Available methods cannot determine if PUD ever occurs as a primary manifestation of RA.
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P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
May 1989,
Annals of the rheumatic diseases,
D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
August 1987,
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D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
June 1988,
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D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
February 1965,
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D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
January 1965,
The Chicago Medical School quarterly,
D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
July 1991,
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D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
January 1986,
Clinical and experimental rheumatology,
D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
November 1958,
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D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
February 1965,
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D E Malone, and
P A McCormick, and
L Daly, and
B Jones, and
A Long, and
B Bresnihan, and
J Molony, and
D P O'Donoghue
December 1978,
The American journal of nursing,
