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Intravenous cimetidine, 300 mg or 400 mg, or ranitidine, 50 mg, was administered as a single dose to 36 volunteers in a randomized, crossover fashion. Aspirates of gastric juice were obtained after dosing, and the pH, titratable acidity, gastric fluid volume, and gastric acid output were determined from baseline through 71/2 hours for each subject. Each intervention significantly increased pH and suppressed hydrogen ion concentration, gastric fluid volume, and gastric acid output. Both the magnitudes of the changes when compared with baseline and the time of the mean maximum effects were similar in all three drug regimens. The effect of all three interventions on gastric fluid volume and gastric acid output diminished sharply after 6 hours. The data indicate that the gastric secretory response to all three interventions did not differ substantially.
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
July 1985,
The Indian journal of medical research,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
December 1985,
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
January 1984,
Revista de gastroenterologia de Mexico,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
June 1981,
Scandinavian journal of gastroenterology. Supplement,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
June 1981,
Scandinavian journal of gastroenterology. Supplement,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
April 1986,
Annals of internal medicine,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
September 1991,
Arzneimittel-Forschung,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
July 1980,
Postgraduate medical journal,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
December 1985,
Clinical pharmacology and therapeutics,
W O Frank, and
K E Peace, and
M Watson, and
J J Seaman, and
P L Szego, and
A Braverman, and
B Mico, and
B Dickson
January 1982,
Clinical pharmacology and therapeutics,
