BIOMAT Database Logo BIOMAT Database Logo

Hyperphosphatemia-Related False-Positive 99m Tc-Pyrophosphate Myocardial Scan: A Case Report With Endomyocardial Biopsy Result. 2023

Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang

With documented high specificity, 99m Tc-pyrophosphate (PYP) scan enables the diagnosis of transthyretin cardiomyopathy to be made reliably without endomyocardial biopsy in patients who do not have monoclonal gammopathy. We report a case with extensive myocardial uptake of Perugini 3 score in the 3-hour 99m Tc-PYP myocardial SPECT that suggested transthyretin cardiac amyloidosis. However, a followed endomyocardial biopsy revealed no amyloid deposition. In this case, hyperphosphatemia was the most likely and presumptive cause of the false-positive 99m Tc-PYP scan. With this case, our experiences of the potential causes of false-positive results of 99m Tc-PYP are further expanded.

UI MeSH Term Description Entries
D009202 Cardiomyopathies A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS). Myocardial Disease,Myocardial Diseases,Myocardial Diseases, Primary,Myocardial Diseases, Secondary,Myocardiopathies,Primary Myocardial Disease,Cardiomyopathies, Primary,Cardiomyopathies, Secondary,Primary Myocardial Diseases,Secondary Myocardial Diseases,Cardiomyopathy,Cardiomyopathy, Primary,Cardiomyopathy, Secondary,Disease, Myocardial,Disease, Primary Myocardial,Disease, Secondary Myocardial,Diseases, Myocardial,Diseases, Primary Myocardial,Diseases, Secondary Myocardial,Myocardial Disease, Primary,Myocardial Disease, Secondary,Myocardiopathy,Primary Cardiomyopathies,Primary Cardiomyopathy,Secondary Cardiomyopathies,Secondary Cardiomyopathy,Secondary Myocardial Disease
D011228 Prealbumin A tetrameric protein, molecular weight between 50,000 and 70,000, consisting of 4 equal chains, and migrating on electrophoresis in 3 fractions more mobile than serum albumin. Its concentration ranges from 7 to 33 per cent in the serum, but levels decrease in liver disease. Proalbumin,Transthyretin
D011756 Diphosphates Inorganic salts of phosphoric acid that contain two phosphate groups. Diphosphate,Pyrophosphate Analog,Pyrophosphates,Pyrophosphate Analogs,Analog, Pyrophosphate
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001706 Biopsy Removal and pathologic examination of specimens from the living body. Biopsies
D013667 Technetium The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, and atomic number 43. All technetium isotopes are radioactive. Technetium 99m (m Technetium 99m,99m, Technetium
D016698 Technetium Tc 99m Pyrophosphate A radionuclide imaging agent used primarily in scintigraphy or tomography of the heart to evaluate the extent of the necrotic myocardial process. It has also been used in noninvasive tests for the distribution of organ involvement in different types of amyloidosis and for the evaluation of muscle necrosis in the extremities. Tc 99m-Pyrophosphate,99mTc-Pyrophosphate,Diphosphoric Acid, Technetium Salt,Tc-PYP,Technetium Tc 99m Pyrophosphate, Tc(3+) Salt (3:4),Technetium Tc 99m Pyrophosphate, Tc(4+) Salt (1:1),99mTc Pyrophosphate,Tc 99m Pyrophosphate,Tc PYP
D054559 Hyperphosphatemia A condition of abnormally high level of PHOSPHATES in the blood, usually significantly above the normal range of 0.84-1.58 mmol per liter of serum. Hyperphosphatemias

Related Publications

Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
Positive Tc-99m pyrophosphate myocardial scintigraphy in a patient with tuberculous pericarditis.
June 1992, Clinical nuclear medicine,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
False-positive and subsequent false negative Tc-99m sestamibi scan in a case of mediastinal thymoma and hyperparathyroidism.
June 2009, The American surgeon,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
Cardioversion and "false positive" technetium-99m stannous pyrophosphate myocardial scintigrams.
September 1976, Circulation,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
Tc-99m-pyrophosphate bone scan in calcinosis universalis.
July 1980, Clinical nuclear medicine,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
Image of Harrington rods on a 99m Tc-pyrophosphate scan.
September 1979, Clinical nuclear medicine,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
Tc-99m pyrophosphate myocardial imaging in perimyocarditis.
May 1981, Journal of nuclear medicine : official publication, Society of Nuclear Medicine,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
False positive technetium-99m pyrophosphate scintigraphy in a patient with cardiac amyloidosis light chain: Case report.
April 2021, Medicine,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
False-positive Tc-99m HMPAO leukocyte scan secondary to adenocarcinoma of the ileum.
January 2004, Clinical nuclear medicine,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
False-positive result using Tc-99m pertechnetate angiography to determine cause of hyperthyroidism.
August 1992, Clinical nuclear medicine,
Lien-Hsin Hu, and Yu Kuo, and Fu-Pang Chang, and Wei-Ting Wang, and Bang-Hung Yang, and Wen-Sheng Huang, and Yuh-Feng Wang
Evaluation of myocardial revascularization utilizing Tc-99m pyrophosphate.
January 1974, Cardiovascular Research Center bulletin,
Copied contents to your clipboard!