BIOMAT Database Logo BIOMAT Database Logo

Imaging of human atherosclerotic lesions using 123I-low-density lipoprotein. 1986

H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger

In patients suffering from clinically manifest atherosclerosis autologous LDL-labelling has been done using 123I. This technique allows localization of areas with an increased LDL entry as well as a monitoring of kinetics. Normally, no tracer uptake can be seen in the vascular system. Positive camera images, however, can be obtained in pathological areas as early as 60 min after LDL-reinjection. Experimental data and morphological control reveal a very good correlation to the gamma-camera findings. The technique seems to be very promising for diagnosis in patients suffering from atherosclerosis and hyperlipoproteinemia.

UI MeSH Term Description Entries
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D008077 Lipoproteins, LDL A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues. Low-Density Lipoprotein,Low-Density Lipoproteins,beta-Lipoprotein,beta-Lipoproteins,LDL(1),LDL(2),LDL-1,LDL-2,LDL1,LDL2,Low-Density Lipoprotein 1,Low-Density Lipoprotein 2,LDL Lipoproteins,Lipoprotein, Low-Density,Lipoproteins, Low-Density,Low Density Lipoprotein,Low Density Lipoprotein 1,Low Density Lipoprotein 2,Low Density Lipoproteins,beta Lipoprotein,beta Lipoproteins
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011877 Radionuclide Imaging The production of an image obtained by cameras that detect the radioactive emissions of an injected radionuclide as it has distributed differentially throughout tissues in the body. The image obtained from a moving detector is called a scan, while the image obtained from a stationary camera device is called a scintiphotograph. Gamma Camera Imaging,Radioisotope Scanning,Scanning, Radioisotope,Scintigraphy,Scintiphotography,Imaging, Gamma Camera,Imaging, Radionuclide
D001743 Urinary Bladder A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION. Bladder,Bladder Detrusor Muscle,Detrusor Urinae,Bladder Detrusor Muscles,Bladder, Urinary,Detrusor Muscle, Bladder,Detrusor Muscles, Bladder
D002339 Carotid Arteries Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery. Arteries, Carotid,Artery, Carotid,Carotid Artery
D005260 Female Females

Related Publications

H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
[Evaluation of biodistribution and imaging of atherosclerotic lesions using 111In-labeled low-density lipoprotein].
July 1993, Kaku igaku. The Japanese journal of nuclear medicine,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
Expression of lectinlike oxidized low-density lipoprotein receptor-1 in human atherosclerotic lesions.
June 1999, Circulation,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
Oxidized low-density lipoprotein receptor LOX-1 and apoptosis in human atherosclerotic lesions.
July 2002, Journal of cardiovascular pharmacology and therapeutics,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
Expression of very low density lipoprotein receptor mRNA in rabbit atherosclerotic lesions.
December 1996, The American journal of pathology,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
APO low density lipoprotein localization. Intracranial and extracranial atherosclerotic lesions from human normolipoproteinemics and hyperlipoproteinemics.
September 1975, Archives of neurology,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
[Distribution and quantification of oxidative low density lipoprotein in the development of atherosclerotic lesions of human aorta].
August 1996, Zhonghua bing li xue za zhi = Chinese journal of pathology,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
Low-density lipoprotein concentration in interstitial fluid from human atherosclerotic lesions. Relation to theories of endothelial damage and lipoprotein binding.
December 1983, Biochimica et biophysica acta,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
Transition metal ions within human atherosclerotic lesions can catalyse the oxidation of low density lipoprotein by macrophages.
October 1995, FEBS letters,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
Vascular 131I-low-density lipoprotein imaging in patients with hypertension and early atherosclerotic lesions in the carotid artery.
August 1999, VASA. Zeitschrift fur Gefasskrankheiten,
H Sinzinger, and H Bergmann, and J Kaliman, and P Angelberger
T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein.
April 1995, Proceedings of the National Academy of Sciences of the United States of America,
Copied contents to your clipboard!