The survival of adrenal gland implantation in the cerebral cortex of the rat was studied. In the present study, mature adrenal gland had survived after six months of implantation. No scar tissue was observed between the adrenal gland cortex and the host cerebral cortex. The implanted tissue showed some reorganization in its cortex and medulla. In the adrenal cortex there was an observable increase in connective tissue fibers and some degeneration of cells. In the medulla, again, both surviving and degenerating cells were observed. This study shows that mature adrenal gland has the capacity to survive after implantation in the cerebral cortex of the rats. Further studies are being carried out on fetal and mature tissue implantation and the ability of the adrenal medulla to secrete catecholamines.