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The structural changes in kidneys of diabetic rats induced by streptozotocin were compared with those of age-matched control animals. Degenerative changes were found in the distal tubules of diabetic rats as early as 2 weeks following the onset of diabetes and by one month the entire distal tubule was severely affected. Fibrinoid lesions were also found in diabetic rats after 4 weeks of the disease and became more frequent subsequently. IgG, albumin but not C3 were also found in the glomerular basement membrane of diabetic rats. Diabetic glomerulosclerosis was present only after several weeks, affected glomeruli showed diffuse mesangial sclerosis and only occasionally nodular sclerosis. Diabetic animals developed renal cortical adenomas and mesenchymal tumours after several months.
L C Yong, and
A F Bleasel
June 1982,
The American journal of physiology,
L C Yong, and
A F Bleasel
June 2014,
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas,
L C Yong, and
A F Bleasel
September 1986,
The Journal of pharmacology and experimental therapeutics,
L C Yong, and
A F Bleasel
December 1993,
Journal of the American Society of Nephrology : JASN,
L C Yong, and
A F Bleasel
April 1993,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
L C Yong, and
A F Bleasel
April 1987,
The Journal of pharmacology and experimental therapeutics,
L C Yong, and
A F Bleasel
June 1979,
Virchows Archiv. A, Pathological anatomy and histology,
L C Yong, and
A F Bleasel
June 1982,
Acta medica Okayama,
L C Yong, and
A F Bleasel
April 1977,
Diabetes,
L C Yong, and
A F Bleasel
January 2019,
Frontiers in physiology,
