Biomaterial Database

Inhibition of aldosterone synthesis induced by flow-stop in the Mongolian gerbil adrenal gland superfused in vitro. 1986

M Fenske

Stopping of superfusion flow for short periods resulted in a significant accumulation of aldosterone within the Mongolian gerbil adrenal gland superfused in vitro. Aldosterone amounts in the first 2-min samples after the re-starting of superfusion were positively correlated with the length of flow-stop; however, they were significantly lower than calculated amounts: 5-min stop: 37 +/- 1% inhibition, 10-min stop: 51 +/- 1% inhibition. In addition, aldosterone secretion was significantly suppressed during prolonged incubation. The results suggest that aldosterone and glucocorticosteroid amounts in adrenal tissue may modulate basal corticosteroidogenesis and that self-suppression forms an important part of the control mechanisms involved in corticosteroidogenesis.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D010477	Perfusion	Treatment process involving the injection of fluid into an organ or tissue.	Perfusions
D005849	Gerbillinae	A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.	Gerbils,Jird,Meriones,Psammomys,Rats, Sand,Gerbil,Jirds,Merione,Rat, Sand,Sand Rat,Sand Rats
D000311	Adrenal Glands	A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.	Adrenal Gland,Gland, Adrenal,Glands, Adrenal
D000450	Aldosterone	A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.	Aldosterone, (+-)-Isomer,Aldosterone, (11 beta,17 alpha)-Isomer
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D066298	In Vitro Techniques	Methods to study reactions or processes taking place in an artificial environment outside the living organism.	In Vitro Test,In Vitro Testing,In Vitro Tests,In Vitro as Topic,In Vitro,In Vitro Technique,In Vitro Testings,Technique, In Vitro,Techniques, In Vitro,Test, In Vitro,Testing, In Vitro,Testings, In Vitro,Tests, In Vitro,Vitro Testing, In