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The extrinsically denervated and vascularly perfused stomach of the hyperthyroid rat exhibits an increased basal gastrin release and an exaggerated response to stimulation with the b-agonist isoproterenol. The b-blocker propranolol does not inhibit the increased basal release of gastrin, but completely blocks the effect of isoproterenol. Vagal stimulation is not different between hyperthyroid and euthyroid rats. We conclude, that there are two mechanisms which are responsible for the increased release of gastrin in hyperthyroidism: firstly a direct effect of thyroid hormones on gastrin cells, and secondly an increase in sensitivity of gastrin cells towards b-adrenergic stimulation.
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
February 1986,
Biochemical pharmacology,
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
January 2005,
Cell biochemistry and biophysics,
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
February 1989,
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M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
October 1980,
Biochimica et biophysica acta,
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
August 1988,
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M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
June 1975,
Endocrinology,
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
March 1978,
Gut,
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
February 1999,
Canadian journal of physiology and pharmacology,
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
August 1977,
American journal of surgery,
M K Müller, and
R Pederson, and
T Olbricht, and
H Goebell
July 1987,
La Clinica terapeutica,
