Biomaterial Database

Ia-Type alloantigens and humoral autoimmune responsiveness in insulin-dependent diabetes mellitus. 1979

H Ludwig, and G Schernthaner, and W R Mayr

In the search for markers either closely linked to or identical with the hypothetical "diabetogenic major histocompatibility gene," immune region-associated alloantigens were defined in 80 patients with insulin-dependent diabetes and in 107 controls. A close association between the Ia-type alloantigen DRw3 and DRw4 and insulin-dependent diabetes was obtained. DRw3 was found in 36% and DRw4 in 32% of the patients compared to 11% and 16%, respectively, of the controls. In addition, a significant influence of DRw3 and humoral anti-islet-cell autoimmunity could be observed, which was found to be due to a high incidence of DRw3 in those patients with islet cell antibody persistence. Islet-cell antibodies (ICA) were observed in 60% of the DRw3-positive patients compared to only 9% of the DRw3-negatives with longstanding disease (greater than 5 yr). These data show a significant association between insulin-dependent diabetes and the Ia-type alloantigens DRw3 (p uncorr. less than 0.0005) and DRw4 (p uncorr. less than 0.025). Furthermore, they provide direct evidence of an association between an Ia-type alloantigen and persisting humoral autoimmune responsiveness in man.

UI	MeSH Term	Description	Entries
D007328	Insulin	A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).	Iletin,Insulin A Chain,Insulin B Chain,Insulin, Regular,Novolin,Sodium Insulin,Soluble Insulin,Chain, Insulin B,Insulin, Sodium,Insulin, Soluble,Regular Insulin
D007515	Islets of Langerhans	Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.	Islands of Langerhans,Islet Cells,Nesidioblasts,Pancreas, Endocrine,Pancreatic Islets,Cell, Islet,Cells, Islet,Endocrine Pancreas,Islet Cell,Islet, Pancreatic,Islets, Pancreatic,Langerhans Islands,Langerhans Islets,Nesidioblast,Pancreatic Islet
D007519	Isoantigens	Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.	Alloantigens,Alloantigen,Isoantigen
D003920	Diabetes Mellitus	A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000906	Antibodies	Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody

Related Publications

H Ludwig, and G Schernthaner, and W R Mayr

Humoral autoimmune aspects of insulin-dependent (type I) diabetes mellitus.

January 1985, Concepts in immunopathology,

H Ludwig, and G Schernthaner, and W R Mayr

[Autoimmune aspects of insulin-dependent diabetes mellitus. Humoral immunity].

January 1987, Problemy endokrinologii,

H Ludwig, and G Schernthaner, and W R Mayr

Autoimmune tolerance and type 1 (insulin-dependent) diabetes mellitus.

December 1992, Diabetologia,

H Ludwig, and G Schernthaner, and W R Mayr

[Autoimmune polyendocrinopathy in insulin-dependent diabetes mellitus].

December 1987, Polski tygodnik lekarski (Warsaw, Poland : 1960),

H Ludwig, and G Schernthaner, and W R Mayr

Humoral autoimmunity in insulin-dependent (type I) diabetes mellitus. A current assessment.

January 1982, Survey of immunologic research,

H Ludwig, and G Schernthaner, and W R Mayr

Cellular and humoral autoimmunity in insulin-dependent diabetes mellitus.

January 1995, Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association,

H Ludwig, and G Schernthaner, and W R Mayr

Lymphocyte responsiveness and interleukin 2 production in type 1 (insulin-dependent) diabetes mellitus.

April 1987, Journal of clinical & laboratory immunology,

H Ludwig, and G Schernthaner, and W R Mayr

[Insulin dependent diabetes mellitus of autoimmune origin].

August 1987, Orvosi hetilap,

H Ludwig, and G Schernthaner, and W R Mayr

Insulin dependent diabetes mellitus, an autoimmune disorder?

November 1989, Clinical immunology and immunopathology,

H Ludwig, and G Schernthaner, and W R Mayr

Type I insulin-dependent diabetes mellitus: a model for autoimmune polygenic disorders.

April 1996, Advances in dental research,