The role of gut-brain axis in a rotenone-induced rat model of Parkinson's disease. 2023

Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
Medical School of the Christus University Center-UNICHRISTUS, Fortaleza, CE, Brazil; Graduate Program in Morphofunctional Sciences, Federal University of Ceará-UFC, Fortaleza, CE, Brazil. Electronic address: julio.santos@alu.ufc.br.

Parkinson's disease (PD) is a widespread neurodegenerative condition affecting millions globally. This investigation centered on the gut-brain axis in a rotenone-induced PD rat model. Researchers monitored behavioral shifts, histological modifications, neurodegeneration, and inflammation markers throughout the rats' bodies. Results revealed that rotenone-treated rats displayed reduced exploration (p = 0.004) and motor coordination (p < 0.001), accompanied by decreased Nissl staining and increased alpha-synuclein immunoreactivity in the striatum (p = 0.009). Additionally, these rats exhibited weight loss (T3, mean = 291.9 ± 23.67; T19, mean = 317.5 ± 17.53; p < 0.05) and substantial intestinal histological alterations, such as shortened villi, crypt architecture loss, and inflammation. In various regions, researchers noted elevated immunoreactivity to ionized binding adapter molecule (IBA)-1 (p < 0.05) and reduced immunoreactivity to glial fibrillary acidic protein (p < 0.05) and S100B (p < 0.001), indicating altered glial cell activity. Overall, these findings imply that PD is influenced by gut-brain axis changes and may originate in the intestine, impacting bidirectional gut-brain communication.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D010300 Parkinson Disease A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75) Idiopathic Parkinson Disease,Lewy Body Parkinson Disease,Paralysis Agitans,Primary Parkinsonism,Idiopathic Parkinson's Disease,Lewy Body Parkinson's Disease,Parkinson Disease, Idiopathic,Parkinson's Disease,Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinsonism, Primary
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D000087502 Brain-Gut Axis An interactive network between the GASTROINTESTINAL TRACT (gut) and the brain principally mediated through the ENTERIC NERVOUS SYSTEM. Control of the gut activities during stress, for instance, is mediated by activation of neuroendocrine hormones (e.g., CORTICOTROPIN-RELEASING FACTOR). Conversely, INTESTINAL MICROBIOTA associate with the CENTRAL NERVOUS SYSTEM through the axis via microorganism-derived products (e.g., UROCORTINS). Some functional GASTROINTESTINAL DISORDERS (e.g., IRRITABLE BOWEL SYNDROME) have dysregulated brain-gut axis. Brain and Gut Axis,Brain-Gut-Microbiome Axis,Gut and Brain Axis,Gut-Brain Axis,Gut-Brain-Microbiome Axis,Microbiome-Brain-Gut Axis,Microbiome-Gut-Brain Axis,Microbiota-Brain-Gut Axis,Microbiota-Gut-Brain Axis,Axis, Brain-Gut,Axis, Brain-Gut-Microbiome,Axis, Gut-Brain,Axis, Gut-Brain-Microbiome,Axis, Microbiome-Brain-Gut,Axis, Microbiome-Gut-Brain,Axis, Microbiota-Brain-Gut,Axis, Microbiota-Gut-Brain,Brain Gut Axis,Brain Gut Microbiome Axis,Gut Brain Axis,Gut Brain Microbiome Axis,Microbiome Brain Gut Axis,Microbiome Gut Brain Axis,Microbiota Brain Gut Axis,Microbiota Gut Brain Axis
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012402 Rotenone A botanical insecticide that is an inhibitor of mitochondrial electron transport.
D051381 Rats The common name for the genus Rattus. Rattus,Rats, Laboratory,Rats, Norway,Rattus norvegicus,Laboratory Rat,Laboratory Rats,Norway Rat,Norway Rats,Rat,Rat, Laboratory,Rat, Norway,norvegicus, Rattus

Related Publications

Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
October 2022, Metabolic brain disease,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
March 2016, Environmental toxicology and pharmacology,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
May 2024, Cold Spring Harbor perspectives in medicine,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
December 2023, Revue neurologique,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
March 2021, Chemistry and physics of lipids,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
February 2020, Neurobiology of disease,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
November 2020, Neuroscience letters,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
September 2017, The American journal of the medical sciences,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
January 2022, Indian journal of pharmacology,
Júlio César Claudino Dos Santos, and Conceição da Silva Martins Rebouças, and Leandro Freitas Oliveira, and Fabrizio Dos Santos Cardoso, and Tyciane de Souza Nascimento, and Alfaete Vieira Oliveira, and Micael Porto Portela Lima, and Geanne Matos de Andrade, and Gerly Anne de Castro Brito, and Glauce Socorro de Barros Viana
February 2015, Behavioural brain research,
Copied contents to your clipboard!