Biomaterial Database

Acute effects of topical forskolin on aqueous humor dynamics in man. 1986

C Seto, and S Eguchi, and M Araie, and S Matsumoto, and M Takase

Previous reports concerning the acute effects of topical forskolin on the intraocular pressure (IOP) and the aqueous humor dynamics in human eyes gave conflicting results, and this led us to reevaluate the effects of this drug in a total of 20 young normal Japanese volunteers. Fifty microliter of 1% forskolin was instilled in one eye, and the vehicle to the fellow control eye. After two instillations of the drug at an interval of 5 minutes, the maximum IOP fall of 2.4 +/- 1.3 mmHg occurred after 1 hour; a single instillation had no significant effect. The effects on the aqueous flow rate and iris permeability factor were determined by the oral fluorescein method. Two instillations of the drug reduced the aqueous flow rate to 87 +/- 7% of the control, while the iris permeability factor was increased to 114 +/- 11% (mean +/- SD, N = 10, P less than 0.005). Pretreatment with topical 0.25% 1-timolol in both eyes 1 hour prior to the drug administration did not significantly alter the forskolin effects.

UI	MeSH Term	Description	Entries
D007429	Intraocular Pressure	The pressure of the fluids in the eye.	Ocular Tension,Intraocular Pressures,Ocular Tensions,Pressure, Intraocular,Pressures, Intraocular,Tension, Ocular,Tensions, Ocular
D007498	Iris	The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
D008297	Male		Males
D010539	Permeability	Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.	Permeabilities
D005260	Female		Females
D005576	Colforsin	Potent activator of the adenylate cyclase system and the biosynthesis of cyclic AMP. From the plant COLEUS FORSKOHLII. Has antihypertensive, positive inotropic, platelet aggregation inhibitory, and smooth muscle relaxant activities; also lowers intraocular pressure and promotes release of hormones from the pituitary gland.	Coleonol,Forskolin,N,N-Dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl Ester HCl,NKH 477,NKH-477,NKH477
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000287	Administration, Topical	The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.	Drug Administration, Topical,Administration, Topical Drug,Topical Administration,Topical Drug Administration,Administrations, Topical,Administrations, Topical Drug,Drug Administrations, Topical,Topical Administrations,Topical Drug Administrations
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults