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In four gastric fistula dogs we studied the effect of cimetidine (5 mg/kg/h) and somatostatin (10 microgram/kg/h), alone or in combination, on gastric secretion stimulated by histamine (160 microgram/kg/h) or pentagastrin (6 microgram/kg/h). Acid and pepsin output after histamine stimulation was more reduced by cimetidine than after pentagastrin stimulation. Somatostatin showed an inhibitory effect only after pentagastrin stimulation. The most effective reduction, both on the degree of inhibition and on duration after cessation of the inhibitors, was seen after the combination of cimetidine/somatostatin. These results give some clinical aspects for the use of these two agents.
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
March 1976,
Gut,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
April 1988,
The American journal of physiology,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
January 1984,
Revista de gastroenterologia de Mexico,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
January 1988,
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
January 1978,
Revista de medicina interna, neurologe, psihiatrie, neurochirurgie, dermato-venerologie. Medicina interna,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
February 1981,
Surgery,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
May 1973,
Zeitschrift fur Gastroenterologie,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
June 1980,
American journal of surgery,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
February 1986,
Gut,
H Bauer, and
G Schmidt, and
W Brückner, and
W Londong, and
F Holle
June 1976,
Gastroenterology,
