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Tibiae from 11-day-old chick embryos, injected with 3H-tetracycline, were autoradiographically analyzed at different stages to localize and study the dynamics of the initial phases of bone mineralization. 3H-tetracycline was localized within newly formed trabeculae, but only at the surfaces of older trabeculae, indicating that the incorporation of tetracycline into bone occurs at active sites of calcification. It takes between 24 and 36 h for injected tetracycline to become stabilized and incorporated into the mineralized matrix. Absence of 3H-tetracycline grains over the osteoblasts suggests a paracellular pathway for incorporation of tetracycline into the mineralizing bone matrix.
H S Sandhu, and
E A Tonna
September 1977,
Cell and tissue kinetics,
H S Sandhu, and
E A Tonna
January 1976,
Neoplasma,
H S Sandhu, and
E A Tonna
October 1978,
Cancer research,
H S Sandhu, and
E A Tonna
July 1983,
Tsitologiia,
H S Sandhu, and
E A Tonna
January 1984,
Acta veterinaria Scandinavica,
H S Sandhu, and
E A Tonna
December 1975,
The Journal of experimental zoology,
H S Sandhu, and
E A Tonna
January 1982,
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition,
H S Sandhu, and
E A Tonna
March 1997,
Hearing research,
H S Sandhu, and
E A Tonna
January 1967,
Radiologia diagnostica,
H S Sandhu, and
E A Tonna
June 1982,
The Journal of comparative neurology,
