Biomaterial Database

Immunoglobulin M rheumatoid factor in patients with mycoplasmal pneumonia. 1986

H Mizutani, and H Mizutani

The relation of IgM rheumatoid factor (IgM-RF) and IgG immune complex (IgG-IC) to clinical aspects of mycoplasmal pneumonia was studied. Serial serum samples obtained from 20 patients with mycoplasmal pneumonia and 4 patients with Mycoplasma pneumoniae infection but without pneumonia were analyzed by sucrose density gradient centrifugation and ELISA. In this study, the following findings were obtained. With the peak concentration of IgM-RF, there was a decrease in pulmonary infiltration concomitant with a decrease in active IgG-IC. With a rapid decrease in IgM-RF, there was an exacerbation concomitant with an increase in active IgG-IC. In some cases the concentrations of IgM-RF were low in the acute phase of the disease and increased in the convalescent phase. Some patients with continuously low concentrations of IgM-RF had prolonged pneumonia. The existence of IgG-IgM-RF complexes in the bloodstream was shown. In this report, it is suggested that IgM-RF might be associated with the recovery or might play a role in the recovery from this pneumonia. Other possible explanations are also discussed.

UI	MeSH Term	Description	Entries
D007074	Immunoglobulin G	The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.	Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075	Immunoglobulin M	A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin.	Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008297	Male		Males
D008970	Molecular Weight	The sum of the weight of all the atoms in a molecule.	Molecular Weights,Weight, Molecular,Weights, Molecular
D011019	Pneumonia, Mycoplasma	Interstitial pneumonia caused by extensive infection of the lungs (LUNG) and BRONCHI, particularly the lower lobes of the lungs, by MYCOPLASMA PNEUMONIAE in humans. In SHEEP, it is caused by MYCOPLASMA OVIPNEUMONIAE. In CATTLE, it may be caused by MYCOPLASMA DISPAR.	Mycoplasma Pneumonia,Pneumonia, Primary Atypical,Mycoplasma dispar Infection,Mycoplasma ovipneumoniae Infection,Mycoplasma pneumoniae Infection,Atypical Pneumonia, Primary,Atypical Pneumonias, Primary,Mycoplasma Pneumonias,Mycoplasma dispar Infections,Mycoplasma ovipneumoniae Infections,Mycoplasma pneumoniae Infections,Pneumonias, Mycoplasma,Pneumonias, Primary Atypical,Primary Atypical Pneumonia,Primary Atypical Pneumonias
D011446	Prospective Studies	Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.	Prospective Study,Studies, Prospective,Study, Prospective
D002499	Centrifugation, Density Gradient	Separation of particles according to density by employing a gradient of varying densities. At equilibrium each particle settles in the gradient at a point equal to its density. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	Centrifugations, Density Gradient,Density Gradient Centrifugation,Density Gradient Centrifugations,Gradient Centrifugation, Density,Gradient Centrifugations, Density
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children