Effect of Glucose Supplementation on Apoptosis in the Pectoralis major of Chickens Raised under Thermoneutral or Heat Stress Environment. 2023

Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
NutriGenomics Laboratory, Department of Poultry Science, University of Georgia, Athens, GA 30602, USA.

Reduced feed intake during heat stress (HS) disrupts glucose homeostasis, thereby resulting in endoplasmic reticulum (ER) stress and triggering apoptosis in chickens. We hypothesize that glucose supplementation could reduce apoptosis in chickens raised under HS. This study comprised 456 28-day-old broiler chickens randomly assigned to four treatment combinations under glucose supplementation and HS. The treatments were TN0, TN6, HS0, and HS6 with two glucose levels (0% and 6%) and two temperature levels (25 °C (thermoneutral-TN) and 35 °C (8.00 AM to 8.00 PM, (HS)). After 7 days post-HS, the blood glucose level for the HS6 group was higher than for TN0, TN6, and HS0. We studied the mRNA expression of genes and caspase-3 activity in the four experimental groups. The expressions of GCN2, ATF4, CHOP, and FOXO3a increased during HS regardless of glucose supplementation, while PERK and MAFbx increased only under HS with glucose supplementation. We show that under TN conditions, glucose supplementation led to a significant increase in cellular apoptosis in the Pectoralis (P.) major. However, under HS with glucose, the level of apoptosis was similar to that of chickens raised under TN conditions with no glucose supplementation. The utility of glucose to curtail apoptosis under HS should be tested under other intense models of HS.

UI MeSH Term Description Entries
D010369 Pectoralis Muscles The pectoralis major and pectoralis minor muscles that make up the upper and fore part of the chest in front of the AXILLA. Pectoralis Major,Pectoralis Major Muscle,Pectoralis Minor,Pectoralis Minor Muscle,Pectoral Muscle,Muscle, Pectoral,Muscle, Pectoralis,Muscle, Pectoralis Major,Muscle, Pectoralis Minor,Muscles, Pectoralis Major,Pectoral Muscles,Pectoralis Major Muscles,Pectoralis Majors,Pectoralis Minor Muscles,Pectoralis Minors,Pectoralis Muscle
D002645 Chickens Common name for the species Gallus gallus, the domestic fowl, in the family Phasianidae, order GALLIFORMES. It is descended from the red jungle fowl of SOUTHEAST ASIA. Gallus gallus,Gallus domesticus,Gallus gallus domesticus,Chicken
D005947 Glucose A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement. Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006358 Hot Temperature Presence of warmth or heat or a temperature notably higher than an accustomed norm. Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis
D018869 Heat-Shock Response A sequence of responses that occur when an organism is exposed to excessive heat. In humans, an increase in skin temperature triggers muscle relaxation, sweating, and vasodilation. Heat-Shock Reaction,Heat Shock,Heat Shock Stress,Heat Stress,Heat-Stress Reaction,Heat-Stress Response,Heat Shock Reaction,Heat Shock Response,Heat Shock Stresses,Heat Shocks,Heat Stress Reaction,Heat Stress Response,Heat Stresses,Heat-Shock Reactions,Heat-Shock Responses,Heat-Stress Reactions,Heat-Stress Responses,Shock, Heat,Stress, Heat,Stress, Heat Shock
D019587 Dietary Supplements Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS. Food Supplements,Neutraceuticals,Dietary Supplementations,Food Supplementations,Herbal Supplements,Nutraceuticals,Nutriceuticals,Dietary Supplement,Food Supplement,Herbal Supplement,Neutraceutical,Nutraceutical,Nutriceutical,Supplement, Food,Supplement, Herbal,Supplementations, Dietary,Supplements, Dietary,Supplements, Food,Supplements, Herbal

Related Publications

Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
January 1989, American journal of veterinary research,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
March 2003, Poultry science,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
July 2016, International journal of biometeorology,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
January 2021, Animals : an open access journal from MDPI,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
November 2023, Animal bioscience,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
October 2021, Tropical animal health and production,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
June 2006, Poultry science,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
July 2023, Poultry science,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
December 2023, Poultry science,
Josephine Kwakye, and Oluwatomide W Ariyo, and Ahmed F A Ghareeb, and Evan Hartono, and Selorm Sovi, and Bikash Aryal, and Marie C Milfort, and Alberta L Fuller, and Romdhane Rekaya, and Samuel E Aggrey
October 2014, Food & function,
Copied contents to your clipboard!