Biomaterial Database

Erythrocyte protoporphyrin in screening for iron deficiency anaemia among children in Nigeria. 1986

T O Odeyemi, and O A Ajayi, and A A Adeyokunnu

Erythrocyte protoporphyrin (EPP) concentration was determined in 87 children who presented at the Adeoyo General Hospital and the University Teaching Hospital (Ibadan, Nigeria) for various ailments. Presence or absence of anaemia was based on haemoglobin concentration. There was a significant difference (p less than 0.01) between the mean haemoglobin values of the severely anaemic, mildly anaemic and control children. There was no significant difference (p greater than 0.05) between the mean haematocrit, mean EPP and mean EPP:Hb ratio of the mildly anaemic and control groups, but corresponding values for the severely anaemic group differed significantly (p less than 0.001) from the values for the others. The increase in EPP was correlated with the decrease in Hb concentration (r = -0.8263, p less than 0.001), suggesting that iron deficiency was a major cause of severe anaemia. EPP alone or in combination with Hb is effective in identifying anaemic individuals, while Hb alone tends to over-estimate the occurrence of iron deficiency anaemia. EPP values above 100 micrograms/100 ml of erythrocytes identified severe anaemia.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D008297	Male		Males
D009549	Nigeria	A republic in western Africa, south of NIGER between BENIN and CAMEROON. Its capital is Abuja.	Federal Republic of Nigeria
D011166	Porphyrins	A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.	Porphyrin
D011524	Protoporphyrins	Porphyrins with four methyl, two vinyl, and two propionic acid side chains attached to the pyrrole rings. Protoporphyrin IX occurs in hemoglobin, myoglobin, and most of the cytochromes.
D002648	Child	A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL.	Children
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005260	Female		Females
D006400	Hematocrit	The volume of packed RED BLOOD CELLS in a blood specimen. The volume is measured by centrifugation in a tube with graduated markings, or with automated blood cell counters. It is an indicator of erythrocyte status in disease. For example, ANEMIA shows a low value; POLYCYTHEMIA, a high value.	Erythrocyte Volume, Packed,Packed Red-Cell Volume,Erythrocyte Volumes, Packed,Hematocrits,Packed Erythrocyte Volume,Packed Erythrocyte Volumes,Packed Red Cell Volume,Packed Red-Cell Volumes,Red-Cell Volume, Packed,Red-Cell Volumes, Packed,Volume, Packed Erythrocyte,Volume, Packed Red-Cell,Volumes, Packed Erythrocyte,Volumes, Packed Red-Cell