Thymic Hyperplasia and Graves Disease: A Nonincidental Association. 2023

Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
Department of Endocrinology and Nutrition, Hospital General Universitario de Castellón, 12004 Castelló de la Plana, Castellón, Spain.

We present 2 cases referred for evaluation of Graves disease (GD) associated with an incidental mediastinal mass. Chest computed tomography (CT) scans showed a 1.2 × 2.4 × 4.3 cm and a 5.7 × 2.6 × 7 cm thymic enlargement, respectively, consistent with thymic hyperplasia (TH) in the 2 patients. Patient 1 had been assessed by thoracic surgery for the mediastinal mass, and thymectomy had been performed to exclude thymoma, with an anatomopathological diagnosis consistent with thymic hyperplasia. Patient 2 was treated with methimazole. CT scan was repeated after he maintained a euthyroid state, which revealed total regression of the mass. There is a well-documented association between these 2 entities, but it is often underdiagnosed and unrecognized in routine clinal practice. The benign evolution, as evidenced by regression of thymic hyperplasia after resolution of the hyperthyroidism, is characteristic. These cases highlight the importance of recognizing the association of GD and TH and warrant a conservative approach, preventing unnecessary thymic evaluation and surgery.

UI MeSH Term Description Entries

Related Publications

Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
December 2013, Surgery,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
February 1971, The Journal of clinical endocrinology and metabolism,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
May 2013, Indian journal of endocrinology and metabolism,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
January 2011, Clinics (Sao Paulo, Brazil),
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
February 2010, Thyroid : official journal of the American Thyroid Association,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
January 2024, BMC endocrine disorders,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
February 2009, Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
February 2001, Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
December 2005, European journal of internal medicine,
Begoña Pla Peris, and Pablo Abellán Galiana, and Francisco Javier Maravall Royo, and Agustín Ángel Merchante Alfaro
January 1990, Pediatric pathology,
Copied contents to your clipboard!