-transparent.png){kind=logo}
To investigate the cardiac effects of enzymatically generated oxygen radicals isolated Langendorff rat heart preparations were perfused with hypoxanthine (0.96 mmol X litre-1) plus xanthine oxidase (0.025 U X ml-1). Oxygen radicals produced an immediate increase in coronary flow. After 10 min a pronounced reduction in contractile performance, as well as in concentrations of high energy phosphates, was seen. Electron microscopical examination showed damage with cellular oedema as a prominent finding. These effects were all effectively reversed by the specific enzymes, superoxide dismutase and catalase, proving that they were due to oxygen radicals.
Related Publications
K Ytrehus, and
R Myklebust, and
O D Mjøs
November 1992,
Diabetologia,
K Ytrehus, and
R Myklebust, and
O D Mjøs
January 1987,
Free radical research communications,
K Ytrehus, and
R Myklebust, and
O D Mjøs
December 1990,
The Journal of surgical research,
K Ytrehus, and
R Myklebust, and
O D Mjøs
November 1998,
Digestive diseases and sciences,
K Ytrehus, and
R Myklebust, and
O D Mjøs
December 2002,
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
K Ytrehus, and
R Myklebust, and
O D Mjøs
June 1967,
The American journal of physiology,
K Ytrehus, and
R Myklebust, and
O D Mjøs
April 1989,
Biochemical and biophysical research communications,
K Ytrehus, and
R Myklebust, and
O D Mjøs
April 1992,
European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies,
K Ytrehus, and
R Myklebust, and
O D Mjøs
January 1987,
Cardiologia (Rome, Italy),
K Ytrehus, and
R Myklebust, and
O D Mjøs
April 2001,
Free radical biology & medicine,
