Impact of corpus callosum integrity on functional interhemispheric connectivity and cognition in healthy subjects. 2024

Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
Department of Radiology, AOU Cagliari, University of Cagliari, Cagliari, Italy. micheleporcu87@gmail.com.

To examine the corpus callosum's (CC) integrity in terms of fractional anisotropy (FA) and how it affects resting-state hemispheric connectivity (rs-IHC) and cognitive function in healthy individuals. Sixty-eight healthy individuals were recruited for the study. The global FA (gFA) and FA values of each CC tract (forceps minor, body, tapetum, and forceps major) were evaluated using diffusion-weighted imaging (DWI) sequences. The homotopic functional connectivity technique was used to quantify the effects of FA in the CC tracts on bilateral functional connectivity, including the confounding effect of gFA. Brain regions with higher or lower rs-IHC were identified using the threshold-free cluster enhancement family-wise error-corrected p-value of 0.05. The null hypothesis was rejected if the p-value was ≤ 0.05 for the nonparametric partial correlation technique. Several clusters of increased rs-IHC were identified in relation to the FA of individual CC tracts, each with a unique topographic distribution and extension. Only forceps minor FA values correlated with cognitive scores. The integrity of CC influences rs-IHC differently in healthy subjects. Specifically, forceps minor anisotropy impacts rs-IHC and cognition more than other CC tracts do.

UI MeSH Term Description Entries
D008279 Magnetic Resonance Imaging Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques. Chemical Shift Imaging,MR Tomography,MRI Scans,MRI, Functional,Magnetic Resonance Image,Magnetic Resonance Imaging, Functional,Magnetization Transfer Contrast Imaging,NMR Imaging,NMR Tomography,Tomography, NMR,Tomography, Proton Spin,fMRI,Functional Magnetic Resonance Imaging,Imaging, Chemical Shift,Proton Spin Tomography,Spin Echo Imaging,Steady-State Free Precession MRI,Tomography, MR,Zeugmatography,Chemical Shift Imagings,Echo Imaging, Spin,Echo Imagings, Spin,Functional MRI,Functional MRIs,Image, Magnetic Resonance,Imaging, Magnetic Resonance,Imaging, NMR,Imaging, Spin Echo,Imagings, Chemical Shift,Imagings, Spin Echo,MRI Scan,MRIs, Functional,Magnetic Resonance Images,Resonance Image, Magnetic,Scan, MRI,Scans, MRI,Shift Imaging, Chemical,Shift Imagings, Chemical,Spin Echo Imagings,Steady State Free Precession MRI
D003071 Cognition Intellectual or mental process whereby an organism obtains knowledge. Cognitive Function,Cognitions,Cognitive Functions,Function, Cognitive,Functions, Cognitive
D003337 Corpus Callosum Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure. Interhemispheric Commissure,Neocortical Commissure,Callosum, Corpus,Callosums, Corpus,Commissure, Interhemispheric,Commissure, Neocortical,Commissures, Interhemispheric,Commissures, Neocortical,Corpus Callosums,Interhemispheric Commissures,Neocortical Commissures
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D016880 Anisotropy A physical property showing different values in relation to the direction in or along which the measurement is made. The physical property may be with regard to thermal or electric conductivity or light refraction. In crystallography, it describes crystals whose index of refraction varies with the direction of the incident light. It is also called acolotropy and colotropy. The opposite of anisotropy is isotropy wherein the same values characterize the object when measured along axes in all directions. Anisotropies
D056324 Diffusion Tensor Imaging The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules. Diffusion Tractography,DTI MRI,Diffusion Tensor MRI,Diffusion Tensor Magnetic Resonance Imaging,Diffusion Tensor MRIs,Imaging, Diffusion Tensor,MRI, Diffusion Tensor,Tractography, Diffusion
D064368 Healthy Volunteers Persons with no known significant health problems who are recruited to participate in research to test a new drug, device, or intervention as controls for a patient group. (from http://clinicalcenter.nih.gov/recruit/volunteers.html, accessed 2/14/2013) Healthy Participants,Healthy Subjects,Human Volunteers,Normal Volunteers,Healthy Participant,Healthy Subject,Healthy Volunteer,Human Volunteer,Normal Volunteer,Participant, Healthy,Participants, Healthy,Subject, Healthy,Subjects, Healthy,Volunteer, Healthy,Volunteer, Human,Volunteer, Normal,Volunteers, Human,Volunteers, Normal

Related Publications

Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
February 2012, Neuroradiology,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
December 2017, Proceedings of the National Academy of Sciences of the United States of America,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
October 2023, Quantitative imaging in medicine and surgery,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
June 2008, The Journal of neuroscience : the official journal of the Society for Neuroscience,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
November 2016, BJPsych open,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
January 2024, Neuropsychologia,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
July 2019, NeuroImage,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
December 2008, Schizophrenia research,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
February 2003, AJNR. American journal of neuroradiology,
Michele Porcu, and Luigi Cocco, and Francesco Marrosu, and Riccardo Cau, and Jasjit S Suri, and Yang Qi, and Victor Pineda, and Andrea Bosin, and Giuliano Malloci, and Paolo Ruggerone, and Josep Puig, and Luca Saba
January 2020, NeuroImage. Clinical,
Copied contents to your clipboard!