Biomaterial Database

Iodination of nutrients in the presence of chlorine based disinfectants used in drinking water treatment. 1986

J P Bercz, and R Bawa

Under conditions simulating the gastrointestinal tract chlorine dioxide (ClO2), HOCl, and NH2Cl caused covalent organification of iodide to nutrient biochemicals. The extent of binding seemed to be proportional to the electromotive force (EMF) and stoichiometry of the redox couple between iodide and the oxidant. Almost half of 71 nutrients examined were found to bind reactive iodine. Iodide was found to inhibit the quinoidal chromogen formation from tyrosine and ClO2, demonstrating the preferential generation of reactive iodine in complex organic mixtures. These findings indicate that ingestion of residual disinfectants via drinking water may pose a health risk in terms of in vivo generation of iodinated organics. Structure, formation, and biological activity of these compounds are under study.

UI	MeSH Term	Description	Entries
D007454	Iodides	Inorganic binary compounds of iodine or the I- ion.	Iodide
D010084	Oxidation-Reduction	A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).	Redox,Oxidation Reduction
D002713	Chlorine	An element with atomic symbol Cl, atomic number 17, and atomic weight 35, and member of the halogen family.	Chlorine Gas,Chlorine-35,Cl2 Gas,Chlorine 35,Gas, Chlorine,Gas, Cl2
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004202	Disinfectants	Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)	Biocide,Disinfectant,Biocides
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000596	Amino Acids	Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.	Amino Acid,Acid, Amino,Acids, Amino
D014881	Water Supply	Means or process of supplying water (as for a community) usually including reservoirs, tunnels, and pipelines and often the watershed from which the water is ultimately drawn. (Webster, 3d ed)	Supplies, Water,Supply, Water,Water Supplies