-transparent.png){kind=logo}
Monovalent vaccination with inactivated SARS-CoV-2 BA.5 protects hamsters against Omicron but not non-Omicron variants. 2023
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
We compared the protective effects of inactivated SARS-CoV-2 vaccines derived from the ancestral and the currently circulating BA.5.2 strains against infection with multiple variants in Syrian golden hamsters. Vaccination with BA.5.2 effectively protected against infection with the Omicron subvariants including XBB.1, but not the Alpha or Delta variant. In contrast, hamsters vaccinated with the ancestral strain demonstrated decent neutralization activity against both the Omicron and non-Omicron variants. Our findings might instruct future design and formulation of SARS-CoV-2 vaccines.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
July 2022,
Vaccines,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
August 2023,
Journal of medical virology,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
July 2022,
Cell discovery,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
August 2023,
The Lancet. Infectious diseases,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
March 2023,
JAMA network open,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
June 2023,
The Lancet. Infectious diseases,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
January 2023,
Nature communications,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
December 2022,
The Lancet. Infectious diseases,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
July 2022,
Nature,
Chon Phin Ong, and
Kaiming Tang, and
Pak-Hin Hinson Cheung, and
Hongzhuo Zhang, and
Tze-Tung Tang, and
Yaqian Xue, and
Junjue Wang, and
Kelvin Kai-Wang To, and
Shuofeng Yuan, and
Zi-Wei Ye, and
Dong-Yan Jin
June 2023,
Microbiology spectrum,
