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Antigenic variation among influenza C virus strains was investigated with monoclonal antibodies against gp88 glycoprotein. Seven monoclonal antibodies obtained were tentatively classified into two groups, A and B. The group A antibodies had hemagglutination inhibition (HI), hemolysis inhibition and neutralization activities whereas the group B antibodies possessed none of them. A comparison of antigenicity among 15 human strains with these antibodies in radioimmunoprecipitation and HI tests showed that the regions recognized by the group A antibodies undergo considerable changes, whereas those by group B are conserved among the strains.
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