Transesophageal two-dimensional echocardiography (TEE) was evaluated in 11 patients who underwent myocardial revascularization. The TEE transducer was positioned to view the left ventricular (LV) short-axis at the level of the papillary muscles (midcavity). Good quality echocardiographic images were obtainable in ten of 11 patients. Global LV function was assessed by measuring LV end-diastolic and end-systolic area and computing the fractional area change (FAC). Measurements of LV areas and FAC had excellent intraobserver reproducibility. Regional LV function was analyzed in two ways after dividing the short-axis view of the LV into four or five anatomic segments. Systolic wall thickening (SWT) of the myocardium was measured in each of four segments by digitization of the endocardial and epicardial borders of the LV and determining the fractional wall thickening. Measurements of SWT were not reproducible, primarily because of a difficulty in delineating the epicardial border of the LV accurately. In the second method, regional wall motion (RWM) in each of five segments was graded according to a previously developed scoring system. RWM analysis proved to be a measurement with excellent interobserver and intraobserver reproducibility. TEE was performed without complication and found to be a reproducible method for assessing global and regional LV function. Quantitative analysis is tedious and, therefore, currently not available on-line in the operating room.