-transparent.png){kind=logo}
Highly Enantioselective Chiral Diol-Catalyzed Conjugate Addition of Boronic Acids to α,β-Unsaturated Trifluoromethyl Ketones. 2023
State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China.
The (R)-3,3'-(3,5-(CF3)2-C6H3)2-BINOL-catalyzed enantioselective conjugate addition of organic boronic acids to α,β-unsaturated 1,1,1-trifluoromethyl ketones affords corresponding addition products bearing a stereogenic center at the β-position in moderate to high yields and excellent enantioselectivities (up to 99% ee), without any 1,2-addition product formation. Moreover, this catalytic protocol features mild reaction conditions, a broad substrate scope, suitability for alkenylboronic acids and (hetero)arylboronic acids, and easy scale-up.
| UI | MeSH Term | Description | Entries |
|---|
Related Publications
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
May 2015,
Chemical communications (Cambridge, England),
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
July 2022,
The Journal of organic chemistry,
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
December 2021,
ACS omega,
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
December 2021,
The Journal of organic chemistry,
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
September 2011,
Chemical communications (Cambridge, England),
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
May 2018,
The Journal of organic chemistry,
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
July 2013,
Organic & biomolecular chemistry,
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
April 2019,
RSC advances,
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
April 2018,
Organic & biomolecular chemistry,
Ya-Jing Hou, and
Lu Zhao, and
Guo-Li Chai, and
Kangbao Zhong, and
Junbiao Chang
July 2016,
Chemistry (Weinheim an der Bergstrasse, Germany),
