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The flight simulator performance decrements resulting from atropine injections were compared to similar decrements resulting from ethanol toxicosis. There were 20 volunteers that received 0.0, 0.5, 1.0, 2.0, and 4.0 X 75 kg-1 of atropine sulfate under double-blind conditions. The performance decrements at each atropine sulfate treatment level for each subject were determined by computing root mean square (RMS) deviations for five flight performance variables. The data set from a previous study concerned with the effects of ethanol on pilot performance was reanalyzed, and the decrements for the five variables at the 0.082% blood alcohol level (BAL) were computed. Probit analysis was used to estimate the effective dose (ED50) at which 50% of the subjects in the atropine sulfate experiment were expected to display decrements in excess of those observed for the 0.082% BAL. The ED50 was 3.12 mg of atropine sulfate.
J A Dellinger, and
H L Taylor, and
B C Richardson
December 1978,
The American journal of gastroenterology,
J A Dellinger, and
H L Taylor, and
B C Richardson
October 1969,
Experientia,
J A Dellinger, and
H L Taylor, and
B C Richardson
March 1966,
Canadian Medical Association journal,
J A Dellinger, and
H L Taylor, and
B C Richardson
November 1961,
Arzneimittel-Forschung,
J A Dellinger, and
H L Taylor, and
B C Richardson
October 1992,
Aviation, space, and environmental medicine,
J A Dellinger, and
H L Taylor, and
B C Richardson
March 1982,
Pharmacology, biochemistry, and behavior,
J A Dellinger, and
H L Taylor, and
B C Richardson
June 1983,
Military medicine,
J A Dellinger, and
H L Taylor, and
B C Richardson
April 1992,
The Annals of pharmacotherapy,
J A Dellinger, and
H L Taylor, and
B C Richardson
May 1986,
The American review of respiratory disease,
J A Dellinger, and
H L Taylor, and
B C Richardson
January 1958,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
