Recent advances in treating female genital human papillomavirus related neoplasms with topical imiquimod. 2023

Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
Obstetrics and Gynecology Unit 1, Sant' Anna Hospital, Department of Surgical Sciences, University of Turin, Turin, Italy.

Human papillomavirus (HPV) encompasses a group of viruses that infect the skin and mucous membranes. In the presence of certain factors, persistent infection with high-risk HPVs can trigger a process of neoplastic transformation. Imiquimod is a topical agent that acts as a Toll-like receptor 7/8 agonist, stimulating the innate and adaptive immune system to exert antitumor and antiviral effects. It has been approved for the treatment of various skin conditions, however, its efficacy and safety in the management of HPV-related-neoplasms of the lower genital tract, such as vulvar, vaginal, and cervical neoplasia, are still under investigation. This review summarizes the current evidence on the use of imiquimod for the treatment of HPV-induced lesions of the female lower genital tract, focusing on its indications, mechanisms of action, outcomes, and predictors of response.

UI MeSH Term Description Entries
D002583 Uterine Cervical Neoplasms Tumors or cancer of the UTERINE CERVIX. Cancer of Cervix,Cancer of the Cervix,Cancer of the Uterine Cervix,Cervical Cancer,Cervical Neoplasms,Cervix Cancer,Cervix Neoplasms,Neoplasms, Cervical,Neoplasms, Cervix,Uterine Cervical Cancer,Cancer, Cervical,Cancer, Cervix,Cancer, Uterine Cervical,Cervical Cancer, Uterine,Cervical Cancers,Cervical Neoplasm,Cervical Neoplasm, Uterine,Cervix Neoplasm,Neoplasm, Cervix,Neoplasm, Uterine Cervical,Uterine Cervical Cancers,Uterine Cervical Neoplasm
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000077271 Imiquimod A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS. 1-Isobutyl-1H-imidazo(4,5-c)quinolin-4-amine,Aldara,R 837,R-837,S 26308,S-26308,Zyclara,R837
D000094302 Human Papillomavirus Viruses A large group of viruses that cause HUMAN PAPILLOMAVIRUS INFECTION, e.g., GENITAL WARTS and cancer of the CERVIX; VAGINA; VULVA; ANUS; or OROPHARYNX. Most common clinically important human papilloma viruses are taxonomically members of ALPHAPAPILLOMAVIRUS and GAMMAPAPILLOMAVIRUS. HPV Human Papillomavirus,Human Papillomavirus,HPV, Human Papillomavirus Viruses,Human Papilloma Virus,HPV Human Papillomaviruses,Human Papilloma Viruses,Human Papillomavirus Virus,Human Papillomavirus, HPV,Human Papillomaviruses,Human Papillomaviruses, HPV,Papilloma Virus, Human,Papillomavirus Virus, Human,Virus, Human Papilloma,Virus, Human Papillomavirus
D000276 Adjuvants, Immunologic Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity. Immunoactivators,Immunoadjuvant,Immunoadjuvants,Immunologic Adjuvant,Immunopotentiator,Immunopotentiators,Immunostimulant,Immunostimulants,Adjuvant, Immunologic,Adjuvants, Immunological,Immunologic Adjuvants,Immunological Adjuvant,Adjuvant, Immunological,Immunological Adjuvants
D014621 Vagina The genital canal in the female, extending from the UTERUS to the VULVA. (Stedman, 25th ed) Vaginas
D014846 Vulvar Neoplasms Tumors or cancer of the VULVA. Cancer of Vulva,Vulvar Cancer,Cancer of the Vulva,Neoplasms, Vulvar,Vulva Cancer,Vulva Neoplasms,Cancer, Vulva,Cancer, Vulvar,Cancers, Vulva,Cancers, Vulvar,Neoplasm, Vulva,Neoplasm, Vulvar,Neoplasms, Vulva,Vulva Cancers,Vulva Neoplasm,Vulvar Cancers,Vulvar Neoplasm
D027383 Papillomaviridae A family of small, non-enveloped DNA viruses infecting birds and most mammals, especially humans. They are grouped into multiple genera, but the viruses are highly host-species specific and tissue-restricted. They are commonly divided into hundreds of papillomavirus "types", each with specific gene function and gene control regions, despite sequence homology. Human papillomaviruses are found in the genera ALPHAPAPILLOMAVIRUS; BETAPAPILLOMAVIRUS; GAMMAPAPILLOMAVIRUS; and MUPAPILLOMAVIRUS.
D030361 Papillomavirus Infections Neoplasms of the skin and mucous membranes caused by papillomaviruses. They are usually benign but some have a high risk for malignant progression. HPV Infection,Human Papillomavirus Infection,HPV Infections,Human Papillomavirus Infections,Papillomavirus Infection,Papillomavirus Infection, Human,Papillomavirus Infections, Human

Related Publications

Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
January 1998, Annales de pathologie,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
January 2001, Acta dermato-venereologica,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
January 1985, Acta cytologica,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
January 2017, F1000Research,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
October 1985, Nihon Hifuka Gakkai zasshi. The Japanese journal of dermatology,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
November 2006, Current oncology reports,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
January 2011, Infectious diseases in obstetrics and gynecology,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
October 2014, Mikrobiyoloji bulteni,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
March 2017, The Journal of dermatology,
Fulvio Borella, and Niccolò Gallio, and Luca Mangherini, and Paola Cassoni, and Luca Bertero, and Chiara Benedetto, and Mario Preti
September 1975, Ginecologia y obstetricia de Mexico,
Copied contents to your clipboard!