-transparent.png){kind=logo}
Thirteen children with medulloblastoma, were studied after 2 to 62 months off radiotherapy and chemotherapy with methotrexate and BCNU. Ages at time of study ranged from 2.3 to 15.7 years. Eleven patients, followed for a mean of 22 months, showed a significant decrease of height score, whereas nine patients had deficient growth hormone (GH) response to provocative tests. Clinical pubertal progression was normal in all patients, and three of five girls with advanced pubertal development had menarche. No evidences of gonadotropin disturbances were found in five patients whereas seven had raised basal follicle-stimulating hormone (FSH) level or FSH response to luteinizing hormone-releasing hormone (LH-RH). Abnormalities in thyrotrophin (TSH) secretion were found in 9 of 13 patients. This study shows that poor growth and GH deficiency were frequent in our patients. The high frequency of thyroid disturbances observed point out the need of evaluating thyroid function for adequate replacement therapy. Perhaps modification of adjuvant chemotherapy in the future can diminish drug-induced gonadal damage.
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
September 1998,
European journal of cancer (Oxford, England : 1990),
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
January 1981,
Acta neurochirurgica,
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
February 1986,
The Journal of pediatrics,
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
April 2004,
Neurology,
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
January 1986,
Medical and pediatric oncology,
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
April 2024,
Annals of pediatric endocrinology & metabolism,
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
October 2022,
Children (Basel, Switzerland),
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
April 2024,
Annals of pediatric endocrinology & metabolism,
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
October 2005,
Arquivos brasileiros de endocrinologia e metabologia,
T Pasqualini, and
B Diez, and
H Domene, and
M E Escobar, and
L Gruñeiro, and
J J Heinrich, and
A Martinez, and
S Iorcansky, and
F Sackmann-Muriel, and
M Rivarola
December 2000,
Archives of pathology & laboratory medicine,
