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Design and Synthesis of Bicyclo[4.3.0]nonene Nucleoside Analogues. 2023
Stephan Scheeff, and
Yan Wang, and
Mao-Yun Lyu, and
Behzad Nasiri Ahmadabadi, and
Sam Chun Kit Hau, and
Tony K C Hui, and
Yufeng Zhang, and
Zhong Zuo, and
Renee Wan Yi Chan, and
Billy Wai-Lung Ng
School of Pharmacy, Faculty of Medicine, The Chinese University of Hong Kong, Shatin , Hong Kong.
Nucleoside analogues are effective antiviral agents, and the continuous emergence of pathogenic viruses demands the development of novel and structurally diverse analogues. Here, we present the design and synthesis of novel nucleoside analogues with a carbobicyclic core, which mimics the conformation of natural ribonucleosides. Employing a divergent synthetic route featuring an intermolecular Diels-Alder reaction, we successfully synthesized carbobicyclic nucleoside analogues with high antiviral efficacy against respiratory syncytial virus.
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