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Challenges in ESI-MS-based Untargeted Metabolomics. 2022

Elena Tobolkina, and Víctor González-Ruiz, and Isabel Meister, and Miguel De Figueiredo, and Davy Guillarme, and Julien Boccard, and Serge Rudaz
School of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland. Elena.Tobolkina@unige.ch.

Untargeted metabolomics is now widely recognized as a useful tool for exploring metabolic changes taking place in biological systems under different conditions. In this article, we aim to provide a short overview of the liquid-phase separation methods hyphenated to MS to perform untargeted metabolomics of biological samples. Each approach is complemented by up-to-date literature to guide readers, as well as practical information for avoiding or fixing some of the most frequently encountered pitfalls. This article covers mainly data acquisition, but a short discussion is provided regarding signal processing and data treatment, as well as data analysis and its biological interpretation in the context of metabolomic studies.

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