-transparent.png){kind=logo}
The temporal course and pathophysiology of penicillamine-induced myasthenia gravis were studied in detail in a typical case. Our results suggest that this disorder and idiopathic autoimmune myasthenia gravis share the same essential pathophysiological features, including the presence of anti-acetylcholine receptor (AChR) antibody, serum-induced blockade of AChRs, antibody-mediated accelerated degradation of AChRs, and a resultant quantitative reduction in available junctional AChRs. An initial severe reduction in junctional AChRs was reversed and the patient recovered, both within 8 months of stopping penicillamine. Our data suggest that penicillamine probably produced myasthenia gravis by initiating a new autoimmune response rather than by enhancing ongoing autoimmunity.
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
September 1983,
Deutsche medizinische Wochenschrift (1946),
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
January 2001,
Ryoikibetsu shokogun shirizu,
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
February 1984,
Journal of the Mississippi State Medical Association,
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
February 1979,
Arthritis and rheumatism,
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
July 1980,
Ugeskrift for laeger,
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
October 2002,
Neurosciences (Riyadh, Saudi Arabia),
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
January 1984,
Duodecim; laaketieteellinen aikakauskirja,
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
January 1985,
American journal of ophthalmology,
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
May 1994,
Schweizerische medizinische Wochenschrift,
R W Kuncl, and
A Pestronk, and
D B Drachman, and
E Rechthand
August 1983,
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke,
