-transparent.png){kind=logo}
MRL-lpr/lpr (MRL/l) mice spontaneously develop an autoimmune disease associated with arthritic manifestations. We used a recently developed mild demineralization procedure, followed by immunohistochemical staining of frozen sections, to investigate cell patterns in the hindlimbs of MRL/l mice at various stages of arthritic disease. Large numbers of Mac-1 (Mas 034)-positive, macrophage-like cells were seen both within the thickened synovial lining layer and in the deeper layers of the synovial tissue in all stages of arthritis. Ia-expressing cells were scarce in the lining layer, but occurred in moderate numbers in the deeper layers of synovial tissue. Lymphocytes were totally absent in MRL/l joints in all stages of arthritis, as demonstrated by lack of staining with Ly-1, Lyt-2, GK 1,5, and antiimmunoglobulin antibodies. Our findings are discussed and related to other types of experimental arthritis and to rheumatoid arthritis in humans.
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
September 1983,
The Journal of experimental medicine,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
June 1995,
Lupus,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
January 1985,
Rheumatology international,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
April 1992,
European journal of immunology,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
September 1987,
Brain, behavior, and immunity,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
April 1985,
Immunology today,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
October 1984,
Journal of immunology (Baltimore, Md. : 1950),
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
May 1991,
Investigative ophthalmology & visual science,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
November 1990,
Pharmacology, biochemistry, and behavior,
A Tarkowski, and
R Jonsson, and
R Holmdahl, and
L Klareskog
March 1984,
Cellular immunology,
