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A spectrum of chemically induced transplantable adenocarcinomas of the rat hepatocyte was developed in inbred strains of rats. For the most part, the tumors showed remarkable stability in growth rate between 1973 and 1976, as determined by months between transfers. A few tumors were slower-growing in 1976 than in 1973, and a few tumors of intermediate growth rate were somewhat slower-growing in 1973 than in 1976. Percentage distributions of chromosomes of six aneuploid hepatoma are presented. The most homogeneous cell lines were a haploid and a hyperdiploid line. The karyotype of each hepatoma had a consistent number of abnormal chromosomes. Lung metastases were observed in almost all cell lines.
H P Morris, and
L J Slaughter
March 1976,
Doklady Akademii nauk SSSR,
H P Morris, and
L J Slaughter
June 1974,
Cancer research,
H P Morris, and
L J Slaughter
March 1970,
Cancer research,
H P Morris, and
L J Slaughter
February 1982,
The Anatomical record,
H P Morris, and
L J Slaughter
March 1985,
Cancer letters,
H P Morris, and
L J Slaughter
January 1976,
Advances in enzyme regulation,
H P Morris, and
L J Slaughter
September 1971,
Cancer research,
H P Morris, and
L J Slaughter
February 1970,
Cancer research,
H P Morris, and
L J Slaughter
December 1970,
Cancer research,
