-transparent.png){kind=logo}
The selection landscape and genetic legacy of ancient Eurasians. 2024
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
Lundbeck Foundation GeoGenetics Centre, Globe Institute, University of Copenhagen, Copenhagen, Denmark. evan.irvingpease@gmail.com.
The Holocene (beginning around 12,000 years ago) encompassed some of the most significant changes in human evolution, with far-reaching consequences for the dietary, physical and mental health of present-day populations. Using a dataset of more than 1,600 imputed ancient genomes1, we modelled the selection landscape during the transition from hunting and gathering, to farming and pastoralism across West Eurasia. We identify key selection signals related to metabolism, including that selection at the FADS cluster began earlier than previously reported and that selection near the LCT locus predates the emergence of the lactase persistence allele by thousands of years. We also find strong selection in the HLA region, possibly due to increased exposure to pathogens during the Bronze Age. Using ancient individuals to infer local ancestry tracts in over 400,000 samples from the UK Biobank, we identify widespread differences in the distribution of Mesolithic, Neolithic and Bronze Age ancestries across Eurasia. By calculating ancestry-specific polygenic risk scores, we show that height differences between Northern and Southern Europe are associated with differential Steppe ancestry, rather than selection, and that risk alleles for mood-related phenotypes are enriched for Neolithic farmer ancestry, whereas risk alleles for diabetes and Alzheimer's disease are enriched for Western hunter-gatherer ancestry. Our results indicate that ancient selection and migration were large contributors to the distribution of phenotypic diversity in present-day Europeans.
Related Publications
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
December 2015,
Nature,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
April 1998,
Science (New York, N.Y.),
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
August 2023,
Biological research,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
December 2018,
Genes,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
May 2015,
American journal of human genetics,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
January 2012,
Archives of trauma research,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
June 1974,
The Library,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
May 2002,
Genetics,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
November 2016,
American journal of human genetics,
Evan K Irving-Pease, and
Alba Refoyo-Martínez, and
William Barrie, and
Andrés Ingason, and
Alice Pearson, and
Anders Fischer, and
Karl-Göran Sjögren, and
Alma S Halgren, and
Ruairidh Macleod, and
Fabrice Demeter, and
Rasmus A Henriksen, and
Tharsika Vimala, and
Hugh McColl, and
Andrew H Vaughn, and
Leo Speidel, and
Aaron J Stern, and
Gabriele Scorrano, and
Abigail Ramsøe, and
Andrew J Schork, and
Anders Rosengren, and
Lei Zhao, and
Kristian Kristiansen, and
Astrid K N Iversen, and
Lars Fugger, and
Peter H Sudmant, and
Daniel J Lawson, and
Richard Durbin, and
Thorfinn Korneliussen, and
Thomas Werge, and
Morten E Allentoft, and
Martin Sikora, and
Rasmus Nielsen, and
Fernando Racimo, and
Eske Willerslev
October 2016,
PLoS biology,
