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The pharmacokinetics of micronomicin (MCR) as a model drug of aminoglycoside antibiotics (AGs) was studied in man by applying our results previously obtained in rats. Three-compartment open model analysis of combined serum and total body store (T.B.S.) data obtained from multiple dosing in man was done using a non-linear least-squares regression program MULTI. We found large individual variations of MCR disposition in man and these variations did not appear within the serum concentration range measurable with conventional assay methods. This finding suggests that the disposition of AGs, included MCR, cannot be estimated by only plasma or serum level analyses. We conclude that the therapeutic drug monitoring of AGs by using T.B.S. data analysis should be an effective method for controlling therapy with AGs in the clinical setting.
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
May 1986,
International journal of bio-medical computing,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
May 1993,
International journal of bio-medical computing,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
August 1974,
Journal of pharmacokinetics and biopharmaceutics,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
January 1982,
European journal of clinical pharmacology,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
August 1969,
The Journal of clinical investigation,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
February 1980,
Journal of pharmacokinetics and biopharmaceutics,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
May 1989,
Pharmacology & toxicology,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
November 2004,
American journal of physiology. Endocrinology and metabolism,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
April 1980,
Anesthesiology,
M Watanabe, and
N Kaneniwa, and
M Matsumoto, and
K Mashimo
April 1980,
Anesthesiology,
