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Experiences and outcomes of fertility testing in male adolescents with sickle cell disease. 2024

Susan Creary, and Sophia M Liles, and Zachary A Colton, and Charis J Stanek, and Matthew C Hudnall, and Gwendolyn P Quinn, and Leena Nahata
Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, USA.

Adult males with sickle cell disease (SCD) may have abnormal semen parameters, raising the concern that SCD and/or treatments may impact fertility. Yet, studies that include adolescents are lacking. To determine if fertility testing is feasible in male adolescents with SCD, and to explore their experiences and outcomes of fertility testing, 33 adolescents who completed a web-based SCD reproductive health education program were offered a free semen analysis. Five (15%) obtained testing and each had abnormalities. Barriers to testing included lack of time and transportation and discomfort. Findings highlight the need for larger, longitudinal studies using innovative testing approaches.

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