The diagnostic accuracy of the ID NOW COVID-19 point of care test in acute hospital admissions. 2024

Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
Department of Infection Sciences, North Bristol Trust, Bristol BS10 5NB, United Kingdom. Electronic address: Ameeka.thompson@nbt.nhs.uk.

BACKGROUND Prompt identification of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection on admission to hospital is crucial to ensuring initiation of appropriate treatment, optimising infection control and maintaining patient flow. The Abbott ID NOW™ COVID-19 assay (ID NOW) is a point-of-care, isothermal nucleic acid amplification test, capable of producing a result within minutes, potentially placing it as an invaluable tool in helping to control the coronavirus-disease 2019 (COVID-19) pandemic. OBJECTIVE To evaluate the diagnostic accuracy of ID NOW in acute hospital admissions. METHODS A prospective approach to data collection was undertaken in consecutive patients with ID NOW and Hologic Aptima™ SARS-CoV-2 transcription-mediated amplification assay (Aptima TMA) results, across three hospitals in the south-west of England between 1st March and 30th September 2021. A nasal swab was taken for ID NOW and a combined nose and throat swab for Aptima TMA. Measures of diagnostic accuracy were calculated for ID NOW against Aptima TMA. This study was conducted during a period of alpha and delta strain predominance. RESULTS 19,698 ID NOW assays were performed, of which 12,821 had an Aptima TMA assay performed within 24 hours. ID NOW had sensitivity of 85.2 % (95 % CI, 82.2-87.9) and specificity of 99.6 % (95 % CI, 99.4-99.7) compared with the reference assay. The overall PPV was 91.0 % (95 % CI, 88.5-93.0) and the overall NPV was 99.3 % (95 % CI, 99.1-99.4). CONCLUSIONS ID NOW offers a valid diagnostic tool to detect SARS-CoV-2, performing comparably to a reference laboratory-based assay which takes longer to provide results.

UI MeSH Term Description Entries
D006761 Hospitals Institutions with an organized medical staff which provide medical care to patients. Hospital
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000067716 Point-of-Care Testing Allows patient diagnoses in the physician’s office, in other ambulatory setting or at bedside. The results of care are timely, and allow rapid treatment to the patient. (from NIH Fact Sheet Point-of-Care Diagnostic Testing, 2010.) Bedside Testing,Point-Of-Care Diagnostic Testing,Point-Of-Care Diagnostic Tests,Point-Of-Care Diagnostics,Point-Of-Care Test,Point-Of-Care Tests,Point of Care Testing,Diagnostic Test, Point-Of-Care,Diagnostic Testing, Point-Of-Care,Diagnostic Tests, Point-Of-Care,Diagnostic, Point-Of-Care,Diagnostics, Point-Of-Care,Point Of Care Diagnostic Testing,Point Of Care Diagnostic Tests,Point Of Care Diagnostics,Point Of Care Test,Point Of Care Tests,Point-Of-Care Diagnostic,Point-Of-Care Diagnostic Test,Test, Point-Of-Care,Test, Point-Of-Care Diagnostic,Testing, Bedside,Testing, Point-Of-Care Diagnostic,Testing, Point-of-Care,Tests, Point-Of-Care,Tests, Point-Of-Care Diagnostic
D000086382 COVID-19 A viral disorder generally characterized by high FEVER; COUGH; DYSPNEA; CHILLS; PERSISTENT TREMOR; MUSCLE PAIN; HEADACHE; SORE THROAT; a new loss of taste and/or smell (see AGEUSIA and ANOSMIA) and other symptoms of a VIRAL PNEUMONIA. In severe cases, a myriad of coagulopathy associated symptoms often correlating with COVID-19 severity is seen (e.g., BLOOD COAGULATION; THROMBOSIS; ACUTE RESPIRATORY DISTRESS SYNDROME; SEIZURES; HEART ATTACK; STROKE; multiple CEREBRAL INFARCTIONS; KIDNEY FAILURE; catastrophic ANTIPHOSPHOLIPID ANTIBODY SYNDROME and/or DISSEMINATED INTRAVASCULAR COAGULATION). In younger patients, rare inflammatory syndromes are sometimes associated with COVID-19 (e.g., atypical KAWASAKI SYNDROME; TOXIC SHOCK SYNDROME; pediatric multisystem inflammatory disease; and CYTOKINE STORM SYNDROME). A coronavirus, SARS-CoV-2, in the genus BETACORONAVIRUS is the causative agent. 2019 Novel Coronavirus Disease,2019 Novel Coronavirus Infection,2019-nCoV Disease,2019-nCoV Infection,COVID-19 Pandemic,COVID-19 Pandemics,COVID-19 Virus Disease,COVID-19 Virus Infection,Coronavirus Disease 2019,Coronavirus Disease-19,SARS Coronavirus 2 Infection,SARS-CoV-2 Infection,Severe Acute Respiratory Syndrome Coronavirus 2 Infection,COVID19,2019 nCoV Disease,2019 nCoV Infection,2019-nCoV Diseases,2019-nCoV Infections,COVID 19,COVID 19 Pandemic,COVID 19 Virus Disease,COVID 19 Virus Infection,COVID-19 Virus Diseases,COVID-19 Virus Infections,Coronavirus Disease 19,Disease 2019, Coronavirus,Disease, 2019-nCoV,Disease, COVID-19 Virus,Infection, 2019-nCoV,Infection, COVID-19 Virus,Infection, SARS-CoV-2,Pandemic, COVID-19,SARS CoV 2 Infection,SARS-CoV-2 Infections,Virus Disease, COVID-19,Virus Infection, COVID-19
D000086402 SARS-CoV-2 A species of BETACORONAVIRUS causing atypical respiratory disease (COVID-19) in humans. The organism was first identified in 2019 in Wuhan, China. The natural host is the Chinese intermediate horseshoe bat, RHINOLOPHUS affinis. 2019 Novel Coronavirus,COVID-19 Virus,COVID19 Virus,Coronavirus Disease 2019 Virus,SARS Coronavirus 2,SARS-CoV-2 Virus,Severe Acute Respiratory Syndrome Coronavirus 2,Wuhan Coronavirus,Wuhan Seafood Market Pneumonia Virus,2019-nCoV,2019 Novel Coronaviruses,COVID 19 Virus,COVID-19 Viruses,COVID19 Viruses,Coronavirus 2, SARS,Coronavirus, 2019 Novel,Coronavirus, Wuhan,Novel Coronavirus, 2019,SARS CoV 2 Virus,SARS-CoV-2 Viruses,Virus, COVID-19,Virus, COVID19,Virus, SARS-CoV-2,Viruses, COVID19
D000086742 COVID-19 Testing Diagnosis of COVID-19 by assaying bodily fluids or tissues for the presence of COVID-19 antibodies, SARS-COV-2 antigens or the VIRAL RNA of SARS-COV-2. 2019 Novel Coronavirus Disease Testing,2019 Novel Coronavirus Testing,2019-nCoV Disease Testing,2019-nCoV Infection Testing,2019-nCoV Testing,COVID-19 Diagnostic Testing,COVID-19 Virus Testing,COVID19 Testing,COVID19 Virus Testing,Coronavirus Disease 2019 Testing,Coronavirus Disease-19 Testing,SARS Coronavirus 2 Testing,SARS-CoV-2 Testing,Severe Acute Respiratory Syndrome Coronavirus 2 Testing,2019 nCoV Disease Testing,2019 nCoV Infection Testing,2019 nCoV Testing,2019-nCoV Disease Testings,2019-nCoV Infection Testings,2019-nCoV Testings,COVID 19 Diagnostic Testing,COVID 19 Testing,COVID 19 Virus Testing,COVID-19 Diagnostic Testings,COVID-19 Testings,COVID-19 Virus Testings,COVID19 Testings,COVID19 Virus Testings,Coronavirus Disease 19 Testing,Coronavirus Disease-19 Testings,Diagnostic Testing, COVID-19,Disease Testing, 2019-nCoV,Infection Testing, 2019-nCoV,SARS CoV 2 Testing,SARS-CoV-2 Testings,Testing, 2019-nCoV,Testing, 2019-nCoV Disease,Testing, 2019-nCoV Infection,Testing, COVID-19,Testing, COVID-19 Virus,Testing, COVID19,Testing, COVID19 Virus,Testing, Coronavirus Disease-19,Testing, SARS-CoV-2,Virus Testing, COVID-19,Virus Testing, COVID19
D012680 Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed) Specificity,Sensitivity,Specificity and Sensitivity
D019411 Clinical Laboratory Techniques Techniques used to carry out clinical investigative procedures in the diagnosis and therapy of disease. Clinical Laboratory Test,Clinical Laboratory Testing,Clinical Laboratory Diagnoses,Clinical Laboratory Testings,Clinical Laboratory Tests,Diagnoses and Laboratory Examinations,Diagnosis, Laboratory,Laboratory Diagnosis,Laboratory Examinations and Diagnoses,Laboratory Techniques, Clinical,Clinical Laboratory Technique,Diagnose, Clinical Laboratory,Laboratory Diagnoses,Laboratory Technique, Clinical,Laboratory Test, Clinical,Laboratory Testing, Clinical,Technique, Clinical Laboratory,Test, Clinical Laboratory,Testing, Clinical Laboratory

Related Publications

Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
May 2022, The Journal of hospital infection,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
December 2021, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
February 2021, Emergency medicine journal : EMJ,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
October 2020, The Journal of infection,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
November 2021, Canadian journal of anaesthesia = Journal canadien d'anesthesie,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
November 2020, The Lancet. Microbe,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
June 2022, Microbiology spectrum,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
September 2022, The clinical respiratory journal,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
February 2021, European journal of clinical investigation,
Ameeka Thompson, and David Hettle, and Stephanie Hutchings, and Barry Vipond, and Nicholas Veasey, and Kerry Grant, and Jonathan Turner, and Rich Hopes, and Jonathan Steer, and Rommel Ravanan, and O Martin Williams, and Peter Muir
July 2023, Journal of clinical microbiology,
Copied contents to your clipboard!