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A quantitative histochemical method (Trident) has been adapted to measure the activities of 4 enzymes, succinate dehydrogenase (SD), isocitrate dehydrogenase (ICD), glucose-6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6-PGD), within the liver acini of the rat during the postnatal developmental period. Quantitative changes of these enzymes in livers of rats of 25 g and 50 g body weight were studied, with particular emphasis on the activity-rest cycle. The results indicate a time-dependent heterogeneous distribution of enzymes along the acinar zones and the pattern of localization is age-dependent. When the mean enzyme activity from each group in relation to the time of the day are compared, a mirror image of each other could be seen. In general, a high enzyme activity has been observed during the resting phase in 25-g rats and low in 50-g rats. During the developmental period, the mean ICD activity is diminished, whereas G6PD and 6-PGD are augmented, and SD activity remains unchanged.
R D Bhattacharya, and
T Araki, and
M Yamada
January 1988,
Cellular and molecular biology,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1983,
Biology of the neonate,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1968,
Physiologia Bohemoslovaca,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1968,
Physiologia Bohemoslovaca,
R D Bhattacharya, and
T Araki, and
M Yamada
December 1979,
Journal of cellular physiology,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1972,
Folia morphologica,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1985,
Enzyme,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1971,
Biology of the neonate,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1989,
Biology of the neonate,
R D Bhattacharya, and
T Araki, and
M Yamada
January 1978,
Drug metabolism and disposition: the biological fate of chemicals,
