We herein report an undisclosed case of systemic lupus erythematosus (SLE) with class 4 lupus nephritis (LN). It is an autoimmune disease that occurs when the body's immune system attacks its tissues. It results in significant tissue damage and inflammation in the afflicted organs. It may affect the kidneys, brain, lungs, skin, joints, and blood vessels. A 30-year-old female presented to Acharya Vinoba Bhave Rural Hospital (AVBRH) with the complaint of breathlessness, cough with expectoration, and fever for two months. The patient is having musculoskeletal renal difficulties and psychological effects. The objective is to reduce the symptoms and to improve the quality of life. A multidisciplinary treatment approach is used, which includes physiotherapy intervention and patient education. In conclusion, this case report mainly focuses on a multidisciplinary treatment approach to improve patient outcomes and quality of life.