Biomaterial Database

Dietary ascorbic acid and selenium relationships in the guinea pig. 1987

B P Poovaiah, and B D Potter, and S T Omaye

Plasma-, erythrocyte- and liver Se-dependent glutathione peroxidase (GPx) activity, ascorbic acid (AA) concentration, and erythrocyte and liver Se levels were analyzed in groups of guinea pigs fed a Torula yeast-based semipurified diet supplemented with either O (-AA), 200 (+AA), or 400 (++AA) mg of AA/kg of diet and either 0.05 (+Se) or 0.2 (++Se) ppm of Se for 24 days. Plasma, erythrocyte, and liver AA concentration were directly related to the levels of AA fed. There were 21.2 +/- 2.7% and 51.2 +/- 4.5% (p less than 0.0001) increases in erythrocyte and liver Se, respectively, in ++Se guinea pigs compared to +Se guinea pigs. Dietary AA had no effect on erythrocyte or liver Se levels. Plasma, erythrocyte, and liver GPx specific activities were significantly (p less than 0.001) increased in ++Se guinea pigs compared to +Se guinea pigs. In addition, liver, plasma, and erythrocyte GPx activities were directly related to the level of AA fed. These data indicate that dietary AA has no influence on tissue levels of Se but increases plasma, liver, and erythrocyte GPx activities in the guinea pig.

UI	MeSH Term	Description	Entries
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D008297	Male		Males
D004032	Diet	Regular course of eating and drinking adopted by a person or animal.	Diets
D004912	Erythrocytes	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing HEMOGLOBIN whose function is to transport OXYGEN.	Blood Cells, Red,Blood Corpuscles, Red,Red Blood Cells,Red Blood Corpuscles,Blood Cell, Red,Blood Corpuscle, Red,Erythrocyte,Red Blood Cell,Red Blood Corpuscle
D005979	Glutathione Peroxidase	An enzyme catalyzing the oxidation of 2 moles of GLUTATHIONE in the presence of HYDROGEN PEROXIDE to yield oxidized glutathione and water.	Cytosolic Glutathione Peroxidase,Glutathione Lipoperoxidase,Selenoglutathione Peroxidase,Glutathione Peroxidase, Cytosolic,Lipoperoxidase, Glutathione,Peroxidase, Glutathione,Peroxidase, Selenoglutathione
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001205	Ascorbic Acid	A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.	Vitamin C,Ascorbic Acid, Monosodium Salt,Ferrous Ascorbate,Hybrin,L-Ascorbic Acid,Magnesium Ascorbate,Magnesium Ascorbicum,Magnesium di-L-Ascorbate,Magnorbin,Sodium Ascorbate,Acid, Ascorbic,Acid, L-Ascorbic,Ascorbate, Ferrous,Ascorbate, Magnesium,Ascorbate, Sodium,L Ascorbic Acid,Magnesium di L Ascorbate,di-L-Ascorbate, Magnesium
D012643	Selenium	An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	Selenium-80,Selenium 80