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The inhibition of pepsin secretion by metiamide and atropine has been studied in the gastric fistula rat and the Heidenhain pouch rat. A comparison of the effectiveness of metiamide and atropine in inhibiting pepsin secretion was made by using doses of the antagonists which produced a similar level of inhibition of acid secretion. In the gastric fistula rat both atropine and metiamide inhibited the basal pepsin output, but atropine was more effective than metiamide in this respect. In the Heidenhain pouch rat a large dose of metiamide which inhibited bethanechol-stimulated acid secretion had no significant effect on the corresponding output of pepsin. In this preparation atropine inhibited both acid and pepsin secretion. Possible reasons for the differences in the two preparations are discussed.
K T Bunce, and
M E Parsons, and
F R Matheson
November 1980,
Agents and actions,
K T Bunce, and
M E Parsons, and
F R Matheson
December 1977,
Experientia,
K T Bunce, and
M E Parsons, and
F R Matheson
February 1977,
The Journal of physiology,
K T Bunce, and
M E Parsons, and
F R Matheson
April 1981,
Agents and actions,
K T Bunce, and
M E Parsons, and
F R Matheson
September 1971,
The Journal of physiology,
K T Bunce, and
M E Parsons, and
F R Matheson
May 1971,
The Journal of physiology,
K T Bunce, and
M E Parsons, and
F R Matheson
April 1977,
The Journal of physiology,
K T Bunce, and
M E Parsons, and
F R Matheson
February 1977,
The American journal of digestive diseases,
K T Bunce, and
M E Parsons, and
F R Matheson
July 1976,
The American journal of digestive diseases,
K T Bunce, and
M E Parsons, and
F R Matheson
April 1969,
Gastroenterology,
