-transparent.png){kind=logo}
Sixty-two patients with pituitary dwarfism were treated with three different preparations of methionyl hGH (m-hGH) for 3 to 14 months. They were given 0.5 IU/kg/week intramuscularly. The growth rate during treatment with the three different preparations was the same for each and increased from 3.5 +/- 0.9 to 8.2 +/- 1.7 cm/year. A high incidence of hGH antibody formation was observed following the treatment, but the titer of antibody was decreased according to the purity of m-hGH preparations. At the end of 12 month treatment with a highly purified preparation (Somatonorm III), 76.2% of the patients had hGH antibody. However, the presence of antibodies did not affect the growth rate except in one patient. No clinical or laboratory side-effects were observed following the treatment with m-hGH. Thus, m-hGH was considered to be useful for the treatment of GH deficient children.
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
January 1970,
Acta paediatrica Scandinavica. Supplement,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
October 1981,
Revista clinica espanola,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
May 1966,
Acta paediatrica Scandinavica,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
January 1986,
Acta paediatrica Scandinavica. Supplement,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
November 1964,
Acta paediatrica,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
January 1968,
Przeglad lekarski,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
April 1984,
Endocrinologia japonica,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
January 1972,
Problemy medycyny wieku rozwojowego,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
May 1974,
Horumon to rinsho. Clinical endocrinology,
K Takano, and
K Shizume, and
N Hizuka, and
A Okuno, and
T Umino, and
Y Kobayashi, and
S Kusano, and
H Nakajima, and
M Irie, and
I Hibi
April 1967,
The Medical journal of Australia,
