-transparent.png){kind=logo}
Experiments are performed to ascertain the mutagenic properties of four new cytostatic methyl-hydrazones in the Ames test using different strains of Salmonella typhimurium. As could be demonstrated all four hydrazones are mutagenic per se without a metabolic activation through rat liver microsomes (S-9 fraction). Whereas the beta-chloroethyl hydrazones B1 and B2 cause a base-pair substitution with the strains TA100 and TA1535 the methyl-hydrazones EB4 and CyB4 both cause base-pair substitution with TA100 and frameshift mutation with TA98. At both strains the mutagenic activity of Cy84 ist powerful. Furthermore, no relation could be detected between the mutagenic properties of the methyl-hydrazones and their alkylating behaviour on 4-(4-nitrobenzyl)-pyridine.
D Gericke, and
R Braun, and
W Dittmar
September 1979,
Mutation research,
D Gericke, and
R Braun, and
W Dittmar
September 1985,
Mutation research,
D Gericke, and
R Braun, and
W Dittmar
September 1976,
Cancer,
D Gericke, and
R Braun, and
W Dittmar
October 1994,
Applied and environmental microbiology,
D Gericke, and
R Braun, and
W Dittmar
January 1999,
International journal of occupational medicine and environmental health,
D Gericke, and
R Braun, and
W Dittmar
March 1993,
Mutation research,
D Gericke, and
R Braun, and
W Dittmar
January 1978,
Journal of agricultural and food chemistry,
D Gericke, and
R Braun, and
W Dittmar
February 1995,
Mutation research,
D Gericke, and
R Braun, and
W Dittmar
November 1978,
Mutation research,
D Gericke, and
R Braun, and
W Dittmar
May 1987,
Bulletin of environmental contamination and toxicology,
