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Tezepelumab and Mucus Plugs in Patients with Moderate-to-Severe Asthma. 2023
Lars H Nordenmark, and
Åsa Hellqvist, and
Claire Emson, and
Sarah Diver, and
Celeste Porsbjerg, and
Janet M Griffiths, and
John D Newell, and
Samuel Peterson, and
Beata Pawlikowska, and
Jane R Parnes, and
Ayman Megally, and
Gene Colice, and
Christopher E Brightling
Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Oslo.
Tezepelumab and Mucus Plugs in Patients with AsthmaMucus plugs in airways of asthma patients are associated with airway obstruction and the activity of inflammatory cytokines. This article reports prespecified and post hoc analyses of the effect of tezepelumab treatment on mucus plugs identified by computed tomography imaging in patients with moderate-to-severe asthma. At baseline, mucus plug scores correlated positively with levels of inflammatory biomarkers and negatively with lung function measures. Patients treated with tezepelumab had resolution of more mucus plugs than patients taking placebo.
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