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Application of Chitosan-Based Hydrogel in Promoting Wound Healing: A Review. 2024

Xueyan Che, and Ting Zhao, and Jing Hu, and Kaicheng Yang, and Nan Ma, and Anning Li, and Qi Sun, and Chuanbo Ding, and Qiteng Ding
College of Traditional Chinese Medicine, Jilin Agriculture Science and Technology University, Jilin City 132101, China.

Chitosan is a linear polyelectrolyte with active hydroxyl and amino groups that can be made into chitosan-based hydrogels by different cross-linking methods. Chitosan-based hydrogels also have a three-dimensional network of hydrogels, which can accommodate a large number of aqueous solvents and biofluids. CS, as an ideal drug-carrying material, can effectively encapsulate and protect drugs and has the advantages of being nontoxic, biocompatible, and biodegradable. These advantages make it an ideal material for the preparation of functional hydrogels that can act as wound dressings for skin injuries. This review reports the role of chitosan-based hydrogels in promoting skin repair in the context of the mechanisms involved in skin injury repair. Chitosan-based hydrogels were found to promote skin repair at different process stages. Various functional chitosan-based hydrogels are also discussed.

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